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Amgen Scientist – Lead Discovery and Characterization in Thousand Oaks, California


You’ve earned your degree. How will you use that achievement to reach your goals? Do more with the knowledge you’ve worked hard to acquire and the passion you already have. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide. Become the professional you are meant to be in this meaningful role.

Scientist – Lead Discovery and Characterization


What you will do

Let’s do this. Let’s change the world. Amgen's Lead Discovery and Characterization laboratory within Therapeutic Discovery is seeking a highly motivated high-throughput mass spectrometry Scientist at Amgen headquarters in Thousand Oaks. In this vital role you will be responsible primarily for the development of Affinity Selection Mass Spectrometry methods for screening and characterizing small molecule ligands of protein targets as part of an integrated drug discovery effort. Additional responsibilities may include the development and execution of mass spectrometric-based enzyme assays, or the characterization of protein-small molecule adducts as part of our efforts toward the discovery of new drugs.

The successful candidate will work closely with biology and chemistry teams to develop new assays and strategies, analyze results, and present and discuss high quality data in a timely manner and should also contribute to skills development and mentoring for colleagues in a highly multi-disciplinary environment.


What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a Scientist with these qualifications.

Basic Qualifications:

Doctoral degree


Master’s degree and 4 years of scientific experience


Bachelor’s degree and 6 years of scientific experience

Preferred Qualifications:

  • Doctoral degree and 2 years of mass spectrometry experience.

  • Deep knowledge of MS techniques especially as applied to Affinity Selection MS or to the high-throughput analysis of protein-small molecule interactions.

  • Experience with the operation, troubleshooting, and maintenance of Q-TOF, QQQ, and/or MALDI mass spectrometers, including the use of LC, SPE, or SEC separation techniques.

  • Familiarity with Agilent, SCIEX, and Bruker instrumentation and software e.g. Agilent MassHunter and SCIEX MultiQuant software.

  • Experience in the development of LC-MS, LC-MS/MS, or SPE-MS methods for affinity selection-based MS assays, MS-detected enzyme assays, or to characterize protein-small molecule adducts.

  • Experience with implementation of high-throughput data analysis packages (e.g. Genedata Screener).

  • Familiarity with the principles of high-throughput screening (HTS) and experience with microplate readers and automated liquid handling systems.

  • An understanding of mechanistic enzymology and biophysical assays (SPR, ITC, NMR) for characterization of protein-ligand binding.

  • Demonstrated ability to work both independently and as a member of a multidisciplinary team.

  • Excellent written and oral communication skills for the timely documentation, presentation, and discussion of science-based results and strategy in a dynamic, multi-disciplinary, team-based environment.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Amgen requires all staff in the United States, Puerto Rico and Canada to be vaccinated from COVID 19 as a condition of employment. In accordance with applicable law, Amgen will provide reasonable accommodations to staff members who qualify on the basis of a medical reason or a sincerely held religious belief, practice, or observance. Such accommodation may not pose an undue hardship to Amgen, its operations, or its staff.