Amgen Scientist- Cardiovascular in Thousand Oaks, California
HOW MIGHT YOU DEFY IMAGINATION?
You’ve earned your degree. How will you use that achievement to reach your goals? Do more with the knowledge you’ve worked hard to acquire and the passion you already have. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide. Become the professional you are meant to be in this meaningful role.
What you will do
Let’s do this. Let’s change the world.
The Department of Cardiometabolic Disorders at AMGEN Inc. is currently seeking a dedicated Scientist to contribute to our research efforts in developing new treatments for cardiovascular diseases. In this vital role you will be responsible for finding innovative therapies to treat cardiometabolic diseases associated with heart failure and obesity. This role requires a commitment to develop a deep understanding of the pathogenic mechanisms that underlie heart failure. The primary focus of this position will be to drive discovery efforts to identify how Amgen’s innovative biological modalities can improve the lives of patients who suffer from heart failure and related co-morbidities.
What we expect of you
We are all different, yet we all use our outstanding contributions to serve patients.
Key Responsibilities include:
Identification of new therapeutic targets and preclinical validation. The candidate is expected to be continuously aware of the scientific cardiovascular developments in cardiovascular disease, with emphasis on heart failure.
Work collaboratively with a team of guide cardiometabolic scientists.
Present research discoveries to AMGEN colleagues and scientific meetings (oral/poster presentations and publish scientific papers in peer-reviewed journals).
Lead ethical high quality research experiments in accordance with regulatory agencies and compliance guidelines.
Facilitate scientific collaborations with academic centers and partners.
Design/assist in the development of medium to low efficiency assays used to support both small and large molecule drug development programs.
Design and complete in vitro, ex vivo, and in vivo cardiovascular studies. It is critical that the candidate is familiar with the pathophysiology of heart diseases.
Independently craft, perform, and analyze laboratory experiments, including troubleshooting, optimization of assays, data collection, interpretation, biostatistical analysis, and presentation.
Participation on cross-functional drug development teams as a key intellectual and technical contributor.
Function efficiently in a team based/collaborative environment as part of a highly coordinated team, possess excellent organizational, verbal, and written communication skills and demonstrate ability to produce reliable and reproducible results.
PhD with degree in biology or related field.
Postdoctoral research experience.
Demonstrated ability in cardiovascular research in industry or academic settings.
Expertise in performing echocardiography and analyzing cardiac function in rodent models of heart disease.
Ideal candidates should have in vivo experience with rodent models of heart failure.
Ability to perform in vitro assays to dissect the mechanism of action of therapeutic molecules in cardiac myocytes, fibroblasts, adipocytes, endothelial cells, and other relevant cardiac cell types.
Ideal candidates should have in vitro experience with cultured cell lines, siRNA transfection techniques, western blotting, quantitative PCR techniques, RNA/DNA isolation, laboratory automation, high content imaging technology, and fluorescence microscopy.
Willing to work in a team environment and possess good laboratory documentation skills.
Some of the vast rewards of working here
As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being.
Full support and career-development resources to expand your skills, enhance your expertise, and maximize your potential along your career journey
A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act
Generous Total Rewards Plan—comprising health, finance and wealth, work/life balance, and career benefits—with compensation and benefits rated above 4 stars (out of 5) on Glassdoor
for a career that defies imagination
Objects in your future are closer than they appear. Join us.
If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.
Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
Amgen requires all staff in the United States, Puerto Rico and Canada to be vaccinated from COVID 19 as a condition of employment. In accordance with applicable law, Amgen will provide reasonable accommodations to staff members who qualify on the basis of a medical reason or a sincerely held religious belief, practice, or observance. Such accommodation may not pose an undue hardship to Amgen, its operations, or its staff.