Amgen Process Development Senior Scientist - Attribute Characterization and Analytical Sciences in Thousand Oaks, California
Attribute Sciences group within Process Development provides scientific and technical expertise to support development and commercialization of Amgen's pipeline of drug candidates. The department identifies and coordinates the achievement of desired product quality attributes towards target product profiles, develops and applies fit-for-purpose analytical methodologies. This position is an exciting opportunity to unlock the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. To be a part of Amgen, the world's leading biotechnology company, that reached millions of patients around the world.
Identifying, characterizing attributes of therapeutic proteins and establishing their biological relevance with respect to efficacy, pharmacokinetics and immunogenicity
Assess a variety of quality attributes of therapeutic proteins with emphasis on chemical modifications including glycosylation, oxidation, deamidation, aspartate isomerization, hydroxylation and others
Develop and apply novel sample preparation and analytical methods for analysis of therapeutic proteins with emphasis on chromatography and mass spectrometry (LC-MS/MS)
Work in an analytical group equipped with several Agilent HPLC systems and mass spectrometers including Thermo Orbitrap, Q-Exactive, Waters Q-TOF mass spectrometers
Perform analyses of therapeutic proteins by LC-MS of intact, reduced protein and peptide mapping, different chromatographic and electrophoretic techniques
Communicate (verbal and written) scientific concepts and results
Follow protocols and procedures, maintain accurate records in an electronic lab notebook, and generate quality data for use in drug development and regulatory filings
Work across organization with other scientists on multidisciplinary teams
Advance projects and studies within deadlines
Create or contribute to patent and publications
Keep current with field of expertise, participate and advance drug development, technologies and information services programs within Amgen
Demonstrate external scientific eminence
Doctorate degree and 2 years of Scientific, Engineering, Applied Mathematics or Bioinformatics experience
Master's degree and 5 years of Scientific, Engineering, Applied Mathematics or Bioinformatics experience
Bachelor's degree and 7 years of Scientific, Engineering, Applied Mathematics or Bioinformatics experience
PhD in Analytical Chemistry or Biochemistry
Documented theoretical knowledge and hand-on experience in peptide mapping of proteins, intact and reduced LC-MS analysis for identification and quantitation of chemical modifications
Training and experience of operating Thermo Orbitrap, Q-Exactive, Waters Q-TOF mass spectrometers, Agilent HPLC
Proficiency with Microsoft Office
Knowledge of statistical processing of data, including related software like Excel, Spotfire, JMP or ArrayStudio
Programming using R, VBasic, C++, machine learning languages
Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.
Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.