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Amgen Process Development Scientist in Thousand Oaks, California

You’ve earned your degree. How will you use that achievement to reach your goals? Do more with the knowledge you’ve worked hard to acquire and the passion you already have. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide. Become the professional you are meant to be in this meaningful role.

Process Development Scientist - Pivotal Attribute Sciences

Amgen is currently seeking a Process Development Scientist, in our Pivotal Attribute Sciences Department in Thousand Oaks, CA. Amgen’s Attribute Sciences (AS) department within the Process Development (PD) organization defines the critical quality characteristics of the therapies it produces and optimizes state-of-the-art analytical tools to guide that development. The Pivotal PD organization’s focus is developing and commercializing robust manufacturing processes across a wide range of therapeutic modalities, including (but not limited to) monoclonal and bispecific antibodies, bispecific T-cell engagers (“BiTEs”), live oncolytic viruses, and synthetic medicines. The PD Scientist will support product characterization and method development to advance clinical candidate molecules through the pivotal stage of development to commercial launch.

Key Responsibilities:

  • Identify and characterize attributes of therapeutic proteins and synthetic molecules using advanced analytical techniques

  • Develop and apply novel sample preparation and analytical methods for analysis of therapeutic proteins and synthetic molecules with emphasis on chromatography and mass spectrometry (LC-MS/MS)

  • Assess a variety of quality attributes of therapeutic proteins with emphasis on chemical modifications including glycosylation, oxidation, deamidation, aspartate isomerization, hydroxylation and others

  • Work in an analytical group equipped with a variety of chromatographic systems and mass spectrometry platforms

  • Perform LC/MS analyses of therapeutic proteins using intact, reduced protein and peptide mapping, different chromatographic and electrophoretic techniques

  • Communicate (verbal and in written) scientific concepts and results

  • Follow protocols and procedures, maintain accurate records in an electronic lab notebook, and generate quality data for use in drug development and regulatory filings

  • Work collaboratively with other scientists on multidisciplinary teams

  • Work independently in advancing projects and studies within required deadlines.

  • Actively create or contribute to patent and publications

  • Keep current with field of expertise, participate and advance drug development, technologies and information services programs within Amgen

We are all different, yet we all use our unique contributions to serve patients. The highly motivated professional we seek is a Scientist with these qualifications.

Basic Qualifications:

  • Doctorate degree or Doctorate degree by December 2021 Or

  • Master’s degree and 4 years of pharmaceutical-biotechnology and/or CRO industry and/or Scientific experience Or

  • Bachelor’s degree and 6 years of pharmaceutical-biotechnology and/or CRO industry and/or Scientific experience

Preferred Qualifications:

  • PhD in Analytical Chemistry, Biochemistry with emphasis in mass spectrometry

  • 2+ year’s post-PhD experience in the pharmaceutical or biotech industry in process and product development and drug substance and drug product analytical method development.

  • Documented theoretical knowledge and hand-on experience in peptide mapping of proteins, intact and reduced LC-MS analysis for identification and quantification of chemical modifications

  • Training and experience of operating Thermo Q-Exactive mass spectrometers and Agilent and Waters HPLCs and UHPLCs

  • Knowledge of statistical processing of data, including related software like Excel, Spotfire & JMP

  • Demonstrated proficiency in solving complex problems, ability to work independently, proactively seek outside resources and collaborate, self-starter and team player with strong leadership and decision-making skills capable of providing mentorship to junior staff

  • Excellent written and verbal communication skills, ability to multitask, effectively plan and follow through on complex projects

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Amgen requires all staff in the United States and Puerto Rico to be vaccinated from COVID 19 as a condition of employment. In accordance with applicable law, Amgen will provide reasonable accommodations to staff members who qualify on the basis of a medical reason or a sincerely held religious belief, practice, or observance. Such accommodation may not pose an undue hardship to Amgen, its operations, or its staff.