Amgen Process Development Scientist in Thousand Oaks, California

Amgen's Process Development Cellular Sciences group aims to establish end-to-end CAR T capabilities. We are seeking a motivated scientist with experience in cellular therapy to join our team.

The Process Development Scientist will be expected to contribute to experimental design and overall project strategy. The ability to work in a team and in a collaborative environment with other members of the organization is essential. The individual would independently conduct experiments and maintain detailed records of procedure and results. More specific responsibilities include:

  • Bioprocessing of human T cells using closed systems (Sepax, CliniMACS, Xuri/WAVE, Sefia) including isolation, enrichment, activation, expansion and cryopreservation

  • T cell characterization using flow cytometry

  • T cell gene transfer via lentiviral transduction

  • Evaluation of non-viral gene delivery methods

Basic Qualifications :

Doctorate degree

OR

Master's degree and 4 years relevant work experience

OR

Bachelor's degree and 6 years relevant work experience

Preferred Qualifications :

  • 2+ years work experience in the cellular therapy space

  • Knowledge of cellular therapy, T cell biology and the current CAR T manufacturing process

  • Experience in culturing PBMCs, human T cells and mammalian cell lines

  • Experience with immunophenotyping using flow cytometry

  • Experience with lentiviral transduction and nucleofection, particularly on T cells

  • Experience with gene editing techniques such as transposons, CRISPR/Cas9, mRNA and LVV

  • Ability to work well as a team

  • Excellent record keeping and communication skills

  • Superb organization and time management skills with the ability to run overlapping experiments

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.