Amgen Process Development Scientist Pivotal Attribute Sciences in Thousand Oaks, California

Attribute Sciences within Process Development provides scientific and technical expertise to support development and commercialization of Amgen's pipeline of drug candidates. The department identifies and coordinates the achievement of desired product quality attributes towards target product profiles, develops and applies fit-for-purpose analytical methodologies. This position is an exciting opportunity to unlock the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics.

Responsibilities include:

Identifying and characterizing attributes of therapeutic proteins and synthetic molecules

Develop and apply novel sample preparation and analytical methods for analysis of therapeutic proteins and synthetic molecules with emphasis on chromatography and mass spectrometry (LC-MS/MS)

Assess a variety of quality attributes of therapeutic proteins with emphasis on chemical modifications including glycosylation, oxidation, deamidation, aspartate isomerization, hydroxylation and others

Work in an analytical group equipped with a variety of chromatographic and mass spectrometry platforms

Perform LC/MS analyses of therapeutic proteins using intact, reduced protein and peptide mapping methods with different chromatographic and electrophoretic techniques

Communicate (verbal and in written) scientific concepts and results

Follow protocols and procedures, maintain accurate records in an electronic lab notebook, and generate quality data for use in drug development and regulatory filings

Work collaboratively with other scientists on multidisciplinary teams

Work independently in advancing projects and studies within required deadlines.

Actively create or contribute to patent and publications

Keep current with field of expertise, participate and advance drug development, technologies and information services programs within Amgen

Demonstrate external scientific eminence

Basic Qualifications

Doctorate degree

OR

Master's degree and 4 years of Scientific, Engineering, Applied Mathematics or Bioinformatics experience

OR

Bachelor's degree and 6 years of Scientific, Engineering, Applied Mathematics or Bioinformatics experience

Preferred Qualifications

PhD in Analytical Chemistry or Biochemistry with emphasis in mass spectrometry

Documented theoretical knowledge and hand-on experience in peptide mapping of proteins, intact and reduced LC-MS analysis for identification and quantitation of chemical modifications

Training and experience of operating Thermo Q-Exactive mass spectrometers and Agilent HPLCs

Proficiency with Microsoft Office

Knowledge of statistical processing of data, including related software like Excel, Spotfire, JMP or ArrayStudio

Programming using R, VBasic, C++, machine learning languages

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.

Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.