Amgen Jobs

Mobile Amgen Logo

Job Information

Amgen Principal Scientist - Targeted Protein Degradation – E3 Ligase Biology Group Leader in Thousand Oaks, California


If you feel like you’re part of something bigger, it’s because you are. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies. We are global collaborators who achieve together—researching, manufacturing, and delivering ever-better products that reach over 10 million patients worldwide. It’s time for a career you can be proud of. Join us.

Principal Scientist - Targeted Protein Degradation – E3 Ligase Biology Group Leader


What you will do

Let’s do this. Let’s change the world. In this vital role you will be a part of Amgen’s Induced Proximity Platform (IPP) team. We are seeking a collaborative Principal Scientist to lead our E3 ubiquitin ligase biology group in Thousand Oaks, California.

The IPP is charged with developing Amgen’s newest drug modality aimed at Targeted Protein Degradation, including discovery of PROTACs and molecular GLUEs.

The Principal Scientist will be a key strategic partner in the IPP responsible for coordinating cross-functional activities.

Job Responsibilities:

  • Responsible for building a multidisciplinary team to support early discovery of Targeted Protein Degradation drugs, including the characterization of E3 ubiquitin ligases.

  • The ideal candidate will have broad laboratory training, deep scientific curiosity and a positive approach to working in a team-based research environment along with a track record of creative problem-solving and enthusiasm for taking on difficult research challenges.

  • Individuals with deep understanding of ubiquitin ligases are particularly encouraged to apply.


What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The Scientific professional we seek is an ambitious leader with these qualifications.

Basic qualifications

Doctorate Degree

Preferred qualifications

  • Demonstrated ability to lead an independent group of scientists

  • Broad knowledge of protein degradation and E3 ubiquitin ligase biology with demonstrated independent research eminence through first and senior author publications in top journals

  • Specific expertise and a record of publication in the biology and biochemistry of E3 ubiquitin ligases.

  • Research experience with biochemical, biophysical, molecular and cellular techniques, including enzyme and cell assay development, characterization of protein modification and turnover, and mechanistic studies of enzymes

  • Strong written/verbal communication and interpersonal skills

  • Demonstrated scientific analysis and problem-solving skills as evidenced in peer review publications.

  • Desire to be a team player in a dynamic, cross-functional environment

  • Experience in drug discovery, particularly in regard to Targeted Protein Degradation strategies


What you can expect of us

As we work to develop treatments that take care of others, so we work to care for our teammates’ professional and personal growth and well-being.

  • Vast opportunities to learn and move up and across our global organization

  • Diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act

  • Generous Total Rewards Plan comprising health, finance and wealth, work/life balance, and career benefits

Apply now

for a career that defies imagination

In our quest to serve patients above all else, Amgen is the first to imagine, and the last to doubt. Join us.

Equal Opportunity Statement

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request an accommodation.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.​