Amgen Principal Scientist - Modeling & Simulation in Thousand Oaks, California
In our mission to serve patients, speed is absolutely critical. We’re rapidly expanding our hiring initiatives and are excited to unite with the most passionate and brilliant scientific minds who want to join our team – working toward our mission of advancing high potential programs for cancer patients around the world.
Amgen Clinical Pharmacology Modeling and Simulation (CPMS) is seeking a Principal Scientist for our Thousand Oaks, CA location. As part of the Clinical Pharmacology, Modeling and Simulation department, the Modeling and Simulation Principal Scientist will support Amgen clinical development and translational sciences programs across multiple therapeutic areas.
Key responsibilities of the Principal Scientist include:
Building pharmacostatistical models to support Population Pharmacokinetics/Pharmacodynamic (PKPD) and exposure-response analyses using relevant state of the art modeling and simulation techniques.
Conducting binary and categorical and binary data analyses, time-to-event (hazard) models, Poisson models, MCMC and Bayesian methods as applied to exposure-response analyses and Population PK and PKPD analysis.
Performing meta-analysis using proprietary and/or literature data.
Participating in cross-functional project teams and providing scientific input for dose selection, early and late study designs using modeling and simulation inputs.
Contributing to clinical pharmacology strategy for the program(s) and implementing project plans.
Generating modeling reports and contributing to the summary documents for regulatory submissions.
Doctorate degree and 3 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experience
Master s degree and 6 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experience
Bachelor s degree and 8 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experience
PhD in pharmaceutical sciences, applied statistics/mathematics, bio-statistics, and/or engineering or related fields with equivalent professional degrees (e. g. MD, PharmD) with 3 years of PK/PD or statistical modeling experience
5 + years industry or relevant academic experience in pharmacometric analyses and/or applied bio-statistics of small molecules and/or biologics.
Proficiency in modeling software (e. g. NONMEM, SAS, R/S-Plus, STAN, MATLAB
We understand that to successfully sustain and grow as a global enterprise and deliver for patients — we must ensure a diverse and inclusive work environment.
Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.
Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people’s lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world’s leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.
If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.
Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.