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Amgen Principal Engineer - Mechanical Discipline Lead in Thousand Oaks, California


If you feel like you’re part of something bigger, it’s because you are. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies. We are global collaborators who achieve together—researching, manufacturing, and delivering ever-better products that reach over 10 million patients worldwide. It’s time for a career you can be proud of.

Principal Engineer – Mechanical Discipline Lead


What you will do

Let’s do this! Let’s change the world!

The Engineering Technical Authority (ETA) within Amgen Corporate Engineering leads the design effort for critical projects and provides technical expertise across Amgen’s global operations network. This position is part of the ETA organization that includes Process Systems, Facilities and Utilities, Site Project Engineering, Maintenance and Metrology functions. The Principal Engineer – Mechanical Discipline Lead will be part of the implementation of capital projects design and delivery teams, among other responsibilities, and will collaborate with the Site Engineering Services Team.

This role applies extensive technical expertise in the coordination of multiple, complex, non-routine projects involving the planning, design, reconfiguration, construction, maintenance and alteration of systems facilities or processes. This position interacts with multiple levels and functions across the organization. Candidate must have strong leadership and communication skills, and the ability to approach technical issues with a science-based mentality while provides clear direction within the area of expertise. In addition, this role provides technical guidance and specification or standard ownership to ensure robust and aligned implementation of Amgen’s mechanical requirements across the company.

The Principal Engineer – Mechanical Discipline Lead deploys engineering expertise from within the company (global and site-based experts) as well as expertise from our industry to optimize Amgen’s assets throughout their life cycle

  • Planning: Translate business needs into engineering technology and design solutions. Lead analysis of alternatives and recommendations for technical solutions in major projects. Lead Engineering in development and execution of corporate initiatives, goals & projects.

  • Design: Lead design and mechanical requirements during the equipment selection of process, utilities, laboratory and building systems to optimize quality and cost across the total life cycle of assets. Ensure appropriate use of technology, and alignment to standards/practices. Approve appropriate exceptions to Amgen standards and specifications.

  • Construction: Provide engineering support during construction, resolve technical issues, and ensure project objectives are met. Ensure commissioning standards are developed and implemented during system qualification.

  • Operations and Maintenance: Assist sites in troubleshooting, and remediation to prevent future occurrence throughout the network. Support the implementation of sustainable and digital solutions to advance performance.

  • Sustainability: Support Amgen’s aggressive environmental sustainability program

Key responsibilities include:

  • Lead or facilitate design and technical decision making for capital projects (Engineering Design Manager)

  • Establish engineering policies for a major segment of the company.

  • Apply advanced technical principles, theories, and concepts in the development of mechanical scope of works for complex to medium capital projects.

  • Advance innovative solutions to complex problems from conception through implementation

  • Interpret, implement, and recommend modifications to company-wide policies.

  • Perform work that involves in-depth investigation of subject area, definition of scope, selection of areas of investigation, and development of novel concept.

  • Conceive plans and conduct engineering research/investigation in areas of considerable scope and complexity.


What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is an employee with these qualifications.

Basic Qualifications:

Doctorate degree in Engineering and 2 years of direct experience in a related technical field


Master’s degree in Engineering and 6 years of direct experience in a related technical field


Bachelor’s degree in Engineering and 8 years of direct experience in a related technical field


Associate’s degree in Engineering and 10 years of direct experience in a related technical field


High school diploma / GED and 12 years of direct experience in a related technical field

Preferred Qualifications:

  • Familiar and/or experience working in a regulated environment, pharmaceutical or biotechnology industries

  • Mechanical expertise, preferably in HVAC design, within the pharmaceutical industry

  • Demonstrated experience in delivery of large capital projects

  • Ability to tactfully negotiate and positively influence peers and executive leadership.

  • Knowledge of applicable regulations (e.g. cGMP, building codes, fire codes, electrical codes, OSHA, LEED, Energy codes) to ensure compliance.

  • Proven ability to provide direction and guidance to external design firms to delivery capital projects

  • Demonstrated ability to effectively lead and partner in a complex, matrixed organizations

  • Ability to provide solutions to a large variety of technical problems of moderate to large complexity and scope

  • The position requires the ability to travel as needed to deliver the project including overnight stays (up to 30%)


  • Join a highly technical team of engineers respected through the company that are responsible for designing Amgen’s innovative facilities

  • Work with multi-functional teams implementing new technologies and continuous improvement at existing sites, resulting in a strong network of subject matter experts across the world

  • Deliver major capital projects and support Amgen’s mission to serve patients by transforming the promise of science and biotechnology into therapies that have the power to restore health or save lives

  • Contribute heavily to Amgen’s sustainability goals including achieve carbon neutrality by 2027, along with a 40% reduction in water used and a 75% reduction in waste disposed.

  • Join a diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act


What you can expect of us

As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being.

The annual base salary range for this opportunity in the U.S. is $140,814 - $ 160,055.

In addition to the base salary, Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:

  • Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.

  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

  • Stock-based long-term incentives

  • Award-winning time-off plans and bi-annual company-wide shutdowns

  • Flexible work models, including remote work arrangements, where possible

Apply now

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancers, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.