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Amgen Postdoctoral Fellow - Selection & Modality Engineering in Thousand Oaks, California


Do more with the knowledge you’re working hard to acquire and the passion you already have. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide. Through this program, you will acquire the valuable hands-on skills and foundational experience to become the professional you are meant to be in your chosen field.

Postdoctoral Fellow – Selection and Modality Engineering


This could be your everyday

Let’s do this. Let’s change the world. During this program, you will be provided with an enriching environment to inspire innovation that will contribute to the development of human therapeutics.

The lab of Dr. Yuan Cheng in the Selection and Modality Engineering Research Department at Amgen is seeking a highly motivated postdoctoral fellow at our state-of-the-art research facility located in Thousand Oaks, Ca.

The duration of the fellowship is 3 years with the option to extend for an additional year. The qualified candidate will work at the interface of chemical biology, biochemistry and synthetic chemistry and apply their skills in developing new technologies and platforms for protein-protein conjugation, generation and screening of hybrid therapeutics. This position will work independently and with various teams including collaboration with academic groups. This position offers flexibility and independence in selecting the course of action and permits exploration of existing and emerging technologies. The Postdoc will publish scientific manuscripts about the developed technologies and their application, as well as any significant discoveries from the use of these technologies.

The initial focus of the postdoctoral fellow will include:

  • Preparation and characterization of protein-protein conjugates

  • Exploration of emerging recombinant protein engineering technologies including genetic code expansion

  • Exploration of new chemical conjugation methods such as site-specific conjugation, enzyme-catalyzed bond formation and bioortogoanal reactions using encoded unnatural amino acids

  • Development of novel chemical conjugation methods

  • Development and implementation of automation platforms for generation and screening of combinatorial conjugate libraries


Here’s what it takes to Win

We are all different, yet we all use our unique contributions to serve patients. The dedicated individual we seek is a scientist with these qualifications.

Basic qualifications

  • PhD at the time of appointment

Preferred qualifications

  • PhD in Biochemistry, Chemical Biology, Chemistry or a related field

  • Cloning, protein expression (mammalian and/or bacterial), purification and analytical methods (incl. HPLC, large molecule mass spec)

  • Experience in bioconjugation and protein chemistry

  • Experience in novel biochemical technology development

  • Knowledge of automation and screening platforms and biological assays

  • Background in structural or computational biology is a plus

  • Excellent written and verbal communication skills

  • Ability to work comfortably within a large team of scientists and engineers with diverse technical and cultural backgrounds

Our culture is what makes Amgen a special place to work. We have a powerful shared purpose around our mission – to serve patients. We respect one another, recognize contributions, and have embedded collaboration, trust, empowerment, and inclusion in all that we do.


Some of the vast rewards of working here

As we work to develop treatments that take care of others, so we work to care for our teammates’ professional and personal growth and well-being.

  • Full support and career-development resources to expand your skills, enhance your expertise, and maximize your potential along your career journey

  • A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act

  • Generous Total Rewards Plan—comprising health, finance and wealth, work/life balance, and career benefits—with compensation and benefits rated above 4 stars (out of 5) on Glassdoor

Equal Opportunity Statement

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request an accommodation.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.​