Amgen Pilot Plant, Manager- Upstream in Thousand Oaks, California

We are seeking a Manager for the Pilot Plant (based in Thousand Oak, CA) working in the Upstream team. This position will execute a variety of production-related operations in a large-scale pilot plant, including but not limited to: performing processing on the floor (cell culture); performing supporting activities such as media preparation, and equipment set-up/cleaning, execution of upstream operations, and managing staff. Work will also include executing production runs, experiments, commercial program support, and characterization efforts. Additional activities will include defining & documenting operation practices, ensuring documentation accurately reflects operations performed, developing and implementing area improvements (efficiency and safety) and lean principles, commissioning equipment, and participating in operations meetings.

The Thousand Oaks Pilot Plant performs frequent piloting of novel process operations (focusing primarily on large molecule cell culture operations), driving technology development, supporting innovation across Amgen's entire spectrum, as well as executing non-GMP and pre-pivotal GMP bioprocessing operations for multiple mammalian and microbial products, to develop & demonstrate production processes and produce bulk material. We produce sound, relevant data for the processes Amgen developments at meaningful scales that enable the rapid, successful transfer of our output to more dedicated manufacturing spaces. The environment is challenging, fast-paced and ever-changing with varying degrees of process definition, but very rewarding for those that like hands-on science and want to make process improvements in a development space. Must be able to work off hours or non-standard shifts.

Basic Qualifications

Doctorate degree

OR

Master's degree and 3 years of Manufacturing and Operations experience

OR

Bachelor's degree and 5 years of Manufacturing and Operations experience

OR

Associate's degree and 10 years of Manufacturing and Operations experience

OR

High school diploma / GED and 12 years of Manufacturing and Operations experience

AND

Previous managerial experience directly managing people and/or experience in leading teams, projects, programs or directing the allocation of resources

Preferred Qualifications

  • Solid knowledge of downstream, as well as a general knowledge of the associated analytical, and buffer preparation techniques

  • Energetic and technically-minded, with strong interpersonal and organizational skills

  • Demonstrate the ability to learn new systems and applications, and various purification techniques

  • Work effectively in team and/or project environments; possess strong math and computer skills, as well as the ability to apply science-based thinking to practical applications

  • Experience in cGMP production environment

  • Bachelor's degree in Biology, Chemistry, or Chemical/Biological Engineering (or other relevant field) and 1 or more years of managerial experience in Life Sciences field

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.