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Amgen Senior Scientist (Small molecule drug discovery) _US Remote in South San Francisco, California


You’ve earned your degree. How will you use that achievement to reach your goals? Do more with the knowledge you’ve worked hard to acquire and the passion you already have. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide. Become the professional you are meant to be in this meaningful role.

Senior Scientist - Pharmacokinetics & Drug Metabolism


What you will do

Let’s do this. Let’s change the world. In this vital role you will be an integral part of Amgen's PKDM department in South San Francisco. We are open to Remote for the right candidate.

The department of pharmacokinetics and drug metabolism (PKDM) within Amgen is dedicated to the discovery and development of novel effective, safe medicines. The successful scientist will work in a team environment to characterize the absorption, distribution, metabolism, excretion and pharmacokinetic properties of therapeutic drug candidates to achieve their full pharmacological potential. PKDM works in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to design promising clinical therapeutic candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.


What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The responsibilities of this PKDM Senior Scientist position will require both a strong laboratory presence as well as the ability to lead others regarding experimental design, data interpretation, and communication of results. This role will also require collaboration with project team representatives (PTR) in support of drug discovery and development studies with a potential to serve as a PKDM PTR for cross-functional program support. Subject matter expertise in small molecule drug metabolizing enzymes and/or transporters is highly desired in addition to the skillsets detailed below.

The ideal candidate will draw from any the following key technical skillsets:

  • Ability to execute experiments to quantitate molecular entities (small molecules, oligonucleotides, biotherapeutics, endogenous proteins or biomarkers) using LC-MS in support of both drug discovery and early development programs

  • Extensive training in the use of biophysical, biochemical, and cell-based analytical methods to interrogate molecular attributes, including drug-target interactions that potentially influence their plasma pharmacokinetics and tissue distribution

  • Experience with primary hepatocyte and/or cell line culture

  • Capable of leveraging PK/PD relationships and in vitro-in vivo extrapolations in support of both drug discovery and early development programs

  • Knowledge of instrument maintenance and troubleshooting as well as electronic laboratory notebook keeping

Basic Qualifications

  • Doctorate degree with 3+ years of industry experience

  • Candidates for the PKDM Senior Scientist position will have a PhD in pharmacology, pharmacokinetic/pharmaceutical sciences, biochemistry, or a related discipline. Experience with small molecule drug discovery and/or development is required.

  • The candidate should possess excellent oral and written communication skills and be able to excel in a highly collaborative, matrixed team environment. Experience with filing IND-enabling reports and written summaries is of benefit.


Some of the vast rewards of working here

As we work to develop treatments that take care of others, so we work to care for our teammates’ professional and personal growth and well-being.

  • Full support and career-development resources to expand your skills, enhance your expertise, and maximize your potential along your career journey

  • A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act

  • Generous Total Rewards Plan—comprising health, finance and wealth, work/life balance, and career benefits—with compensation and benefits rated above 4 stars (out of 5) on Glassdoor

Apply now

for a career that defies imagination

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Equal Opportunity Statement

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request an accommodation.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.

Amgen requires all staff in the United States and Puerto Rico to be vaccinated from COVID 19 as a condition of employment. In accordance with applicable law, Amgen will provide reasonable accommodations to staff members who qualify on the basis of a medical reason or a sincerely held religious belief, practice, or observance. Such accommodation may not pose an undue hardship to Amgen, its operations, or its staff.