Job Information
Amgen Senior Principal Scientist - Molecular Analytics in South San Francisco, California
HOW MIGHT YOU DEFY IMAGINATION?
If you feel like you’re part of something bigger, it’s because you are. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies. We are global collaborators who achieve together—researching, manufacturing, and delivering ever-better products that reach over 10 million patients worldwide. It’s time for a career you can be proud of.
Senior Principal Scientist - Molecular Analytics
Live
What you will do
Let’s do this. Let’s change the world. In this vital role you will be part of the Molecular Analytics group providing scientific and technical expertise to support early discovery research through to later stage molecule optimization and late-stage selection of Amgen’s pipeline of drug candidates. This position is an exciting opportunity to unlock the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics.
Perform protein, peptide, small molecule, nucleic acid, glycan analysis and characterization by mass spectrometry, using RPLC-MS and RPLC-MS/MS, native-MS and other hyphenated MS analytical capabilities to support the diverse early-stage pipeline.
MS and MS/MS based PTM characterization.
MS/MS based de novo sequencing.
Execute and develop sensitive high-throughput, low material consumption assays to assess mAbs, MsAbs, mAb-fusions, ADCs and other biotherapeutics’ physical, chemical, thermal and colloidal stability and manufacturability using multiple analytical techniques, including, but not limited to, liquid chromatography methods such as LC-MS, LC-MS/MS, aSEC, aCEX, aHIC, calorimetry, and light scattering.
Perform epitope and paratope binning, using analytical methods such as HDX-MS, FPOP and other covalent labelling methods
Implement new analytical technologies, including but not limited to MS, that will support the early-stage pipeline.
Lead and mentor a team of diverse scientists across multiple international research sites.
Generate, process and use large analytical data sets for the application of biomolecule attribute and manufacturability prediction and machine learning purposes
Manage timelines, therapeutic projects and cross functional teams and departmental collaborations
Develop collaborations with both internal and external partners. For example, clients in early research protein cloning, expression and purification; process development; university and external research institutes
Communicate (verbal and in written) scientific concepts and results
Work independently in advancing projects and studies within required deadlines
Keep current with field of expertise, participate and advance drug development, technologies and information services programs within Amgen
Demonstrate external scientific eminence in the form of peer-reviewed publications and conference presentations
Follow protocols and procedures, maintain accurate records in an electronic lab notebook, and generate quality data for use in drug development and regulatory filings
Win
What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a scientist with these qualifications.
Basic Qualifications:
Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 3 years of biopharmaceutical Analytical Chemistry, Biochemistry or equivalent
Or
Master’s degree and 6 years of biopharmaceutical Analytical Chemistry, Biochemistry or equivalent
Or
Bachelor’s degree and 8 years of biopharmaceutical Analytical Chemistry, Biochemistry or equivalent
Preferred Qualifications:
PhD or Post-Doc level qualification with an emphasis in mass spectrometric analytical characterization and biological attribute prediction.
A deep understanding of mass spectrometric, proteomics and other protein structural analytical methods and techniques will be advantageous.
5-10 years of biopharmaceutical experience is essential.
Leadership experience is essential.
A track record of publications and conference presentations is essential.
Knowledge of statistical processing of data, including related software such as R-Studio and Jupyter Notebooks Excel, Spotfire, JMP or ArrayStudio.
Knowledge of high-level data interpretation, ideally for both mass spectrometry ad molecule manufacturability will be advantageous.
Knowledge of AI/ML processes is advantageous.
Knowledge of multiple chromatographic softwares (ChemStation, Chromeleon), Astra (SEC-MALS/QELLS), Tecan scripts (automation), TA and NanoTemper (calorimetry) software would be advantageous.
Relevant experience working as part of a multidisciplinary team in a biopharmaceutical setting would also be an advantage.
Thrive
What you can expect of us
As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:
Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans and bi-annual company-wide shutdowns
Flexible work models, including remote work arrangements, where possible
Apply now
for a career that defies imagination
Objects in your future are closer than they appear. Join us.
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Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.