Amgen Jobs

Mobile Amgen Logo

Job Information

Amgen Senior Associate Scientist - PKDM in South San Francisco, California


You’ve earned your degree. How will you use that achievement to reach your goals? Do more with the knowledge you’ve worked hard to acquire and the passion you already have. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide. Become the professional you are meant to be in this meaningful role.

Senior Associate Scientist - Pharmacokinetics & Drug Metabolism


What you will do

Let’s do this. Let’s change the world. In this vital role you will be an integral part of Amgen's PKDM department in South San Francisco.

Job Description

The department of pharmacokinetics and drug metabolism (PKDM) within Amgen is dedicated to the discovery and development of novel effective, safe medicines. The successful scientist will work in a team environment to characterize the absorption, distribution, metabolism, excretion and pharmacokinetic properties of therapeutic drug candidates to achieve their full pharmacological potential. PKDM works in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to design promising clinical therapeutic candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.

The responsibilities of a PKDM Sr. Associate Scientist are to develop and routinely employ in vitro and bioanalytical methods for the quantitative and qualitative analysis of small molecule drug candidates and metabolites in plasma, tissues, and other biological matrices. The role will require data interpretation and communication of results to project team representatives in support of drug discovery and development.

The ideal candidate will have a proven ability to execute experiments to quantitate molecular entities by mass spectrometry in support of both drug discovery and early development programs. This role requires an excellent understanding of preclinical ADME in vitro and bioanalytical techniques and an individual that can work collaboratively in a fast-paced work environment. The candidate will work as a member of the small molecule ADME group and will be responsible for executing enzyme kinetics, in vitro inhibition, metabolite identification, and bioanalytical experiments. The Sr. Associate Scientist should be able to assist in troubleshooting when instrument or assay problems arise. Other responsibilities will include basic biochemistry research, electronic laboratory notebook keeping and communication of results to project teams.


What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a scientist with these qualifications.

Basic Qualifications

  • Master’s degree in chemistry, biochemistry, or equivalent with 0-3 years of experience or a Bachelor's degree and 2-5 years of experience

  • Experience with operation, troubleshooting, and data interpretation of mass spectrometry is required

Preferred Qualifications

  • Experience with operation of automated liquid sample handling instruments and experience with analysis of radiolabeled compounds is desired. The Sr. Associate Scientist should possess excellent oral and written communication skills and excel in a highly collaborative, matrixed team environment.


Some of the vast rewards of working here

As we work to develop treatments that take care of others, so we work to care for our teammates’ professional and personal growth and well-being.

  • Full support and career-development resources to expand your skills, enhance your expertise, and maximize your potential along your career journey

  • A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act

  • Generous Total Rewards Plan—comprising health, finance and wealth, work/life balance, and career benefits—with compensation and benefits rated above 4 stars (out of 5) on Glassdoor

Apply now

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

Equal Opportunity Statement

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request an accommodation.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.​