Amgen Senior Associate - Protein Engineering & Design in South San Francisco, California

Amgen's Therapeutic Discovery organization is seeking an enthusiastic team-oriented Senior Associate to join the structure-based protein engineering group within Protein Technologies. Protein Technologies is responsible for designing, planning, and executing on the generation of key enabling reagents to support early discovery of small and large molecule therapeutics and cutting-edge novel modalities. The structure-based Protein engineering group prosecutes on challenging targets and tool antibodies/cytokines requiring structural consideration and/or engineering. The work in our group involves a blend of structural analysis and protein design as well as experimental protein production and characterization of designed proteins.

The successful candidate will work closely with group members to design, clone, express and purify engineered proteins.


Contribute to the design and engineering of novel protein constructs.

Clone large panels of engineered proteins and novel constructs.

Express and purify engineered proteins.

Basic Qualifications

Master's degree


Bachelor's degree and 2 years scientific expereince

Preferred Qualifications

Broad training in protein biochemistry, including:

  • Knowledge of protein structure and hands-on experience in structure visualization

  • Knowledge of general concepts in protein engineering

  • Hands-on experience in DNA construct design and molecular cloning, preferably Golden Gate or Gibson cloning

  • Understanding of common strategies for protein expression and purification

  • Strong written and verbal communication and interpersonal skills

  • Desire to be a team player in a cross-functional environment

  • Ability to thrive and adapt in a dynamic environment

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.