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Amgen Scientist - Pharmacokinetics and Drug Metabolism in South San Francisco, California


You’ve earned your degree. How will you use that achievement to reach your goals? Do more with the knowledge you’ve worked hard to acquire and the passion you already have. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide. Become the professional you are meant to be in this meaningful role.

Scientist, Pharmacokinetics and Drug Metabolism


What you will do

The department of pharmacokinetics and drug metabolism (PKDM) within Amgen Research is dedicated to the development of novel, effective, and safe medicines. Work in a team environment to characterize the absorption, distribution, metabolism, excretion and pharmacokinetic properties of therapeutic drug candidates to achieve their full pharmacological potential. PKDM works in close partnership with subject areas such as medicinal chemistry, protein sciences, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to design promising clinical therapeutic candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.

Let’s do this. Let’s change the world. The responsibilities of a PKDM Scientist are to develop and employ bioanalytical methods for the quantitative and qualitative analysis of small molecules, proteins, antibodies, and oligonucleotides in plasma, tissues, and other biological matrices. The role will require data interpretation and communication of results to project team representatives in support of drug discovery and development.


What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The ideal candidate will draw from any the following key technical skillsets:

  • Strong background in the use of biophysical, biochemical, and cell-based analytical methods to interrogate molecular attributes, including drug-target interactions that potentially influence their plasma pharmacokinetics and tissue distribution. Cell culture and flow cytometry experience is also of benefit

  • Candidates should have solid expertise in quantitative pharmacology and strong hands-on modeling and simulation skills. Rich hands-on experience with NONMEM, R, Simcyp, GastroPlus, and/or other modeling and simulation software is required. Solid background in PK-PD modeling with an emphasis translation of models across species (animals to humans) is preferred.

Basic Qualifications

PhD degree completion by March 2021


  • Master’s degree with 5 years of experience


  • Doctorate degree with 0-1 years of experience

Candidates for Scientist in PKDM will have PhD or MS in chemistry, biochemistry, biophysics, medicinal chemistry, pharmacology or equivalent. The candidate should possess excellent oral and written communication skills and be able to excel in a highly collaborative, matrixed team environment.


Some of the vast rewards of working here

As we work to develop treatments that take care of others, so we work to care for our teammates’ professional and personal growth and well-being.

  • Full support and career-development resources to expand your skills, enhance your expertise, and maximize your potential along your career journey

  • A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act

  • Generous Total Rewards Plan—comprising health, finance and wealth, work/life balance, and career benefits—with compensation and benefits rated above 4 stars (out of 5) on Glassdoor

Apply now for a career that defies imagination

Objects in your future are closer than they appear. Join us.

Equal Opportunity Statement

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request an accommodation.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.​