Amgen Scientist - Cardiovascular in South San Francisco, California
The Scientist will be directly responsible for executing in vivo cardiovascular preclinical studies with a goal to identify and characterize innovative drug therapies for the treatment of cardiovascular disease. The Scientist will work with preclinical in vivo models for testing therapeutic concepts and will need strong, hands-on technical skill. Working cross-functionally within Amgen, the Scientist will assist in designing in vivo experiments, drafting and implementing protocols, executing studies, organizing data, analyzing results, and drafting reports. Expertise with in vivo and ex vivo cardiovascular techniques are essential.
Executing in vivo cardiovascular PK/PD studies with a goal of identifying novel drug candidates
Extensive experience in atherosclerosis (e.g., genetic and surgical) models and ex vivo microvascular (e.g., mesenteric artery) vascular functional studies. Immunohistochemistry analysis of atherosclerosis lesions.
Development of novel vascular disease models.
In vivo/ex vivo assay development/validation to evaluate the activity of novel compounds and reagents.
Cardiometabolic phenotyping of genetically modified rodents (i.e., knockout and transgenic lines)
Daily animal monitoring, routine dose administration, tissue and fluid sampling, aseptic surgical preparation. Catheterization of major vessels for dosing/sampling
Hands on experience with ELISA for biomarkers. Development of novel ELISA methods for biomarkers.
In vivo assessment of cardiovascular hemodynamics using echocardiography, invasive hemodynamics (PV loop methodology).
Working knowledge of the application/use of IACUC protocols
Master’s degree and 4 years of scientific experience
Bachelor’s degree and 6 years of scientific experience
Ph.D. or Master’s in cardiovascular physiology, vascular biology, life sciences, or related field
Strong record in utilizing in-vivo/ex vivo cardiovascular models to study cardiovascular disease
Proficiency in Graph Pad, Excel and PowerPoint, as well as, with necessary tools for statistical data analysis
Excellent communication skills, troubleshooting skills, pro-active attitude and ability to work productively as part of high-performance teams.