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Amgen Protein Design- Senior Scientist in South San Francisco, California

Amgen’s Discovery Protein Sciences – Protein Design team is looking for a talented Senior Scientist to drive innovation in protein design to support early-stage large molecule discovery. Discovery Protein Sciences is responsible for the delivery of target proteins and early-stage therapeutic proof-of-principle molecules to drive the early stage large and small molecule discovery pipeline. The Protein Design team is an interdisciplinary team of computational and wet lab scientists focused on designing and producing innovative molecules to address challenging problems in early discovery and explore emerging therapeutic concepts. Our team has core capabilities in protein design including de novo design, protein engineering, and molecular biology.

This position is ideally based at our South San Francisco, British Columbia, or Thousand Oaks sites, but we would consider remote from within the United States or Canada for candidates with a track record of productive remote work.

This position is ideal for scientists who enjoy working in a hybrid dry/wet-lab environment.


You’ve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience and passion to work toward your goals? At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role.

Senior Scientist- Protein Design


What you will do

Let’s do this. Let’s change the world. In this vital role you will drive innovation in protein design to support early-stage large molecule discovery.

  • Use and develop computational strategies to tackle difficult structure-based protein design challenges relevant to therapeutic discovery, including for de novo design

  • Work on multiple large molecule modalities such as target proteins, antibodies, and protein therapeutics

  • Stay abreast in the latest developments of computational protein design methodologies and contribute to the continuous development of protein design approaches

  • Develop and optimize computational workflows for efficient data analysis and visualization

  • Collaborate with experimental teams and present findings to cross-functional teams

  • Work with other computational groups at Amgen to align on strategies and projects


What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The vital attribute professional we seek is a type of person with these qualifications.

Basic Qualifications:

Doctorate degree PhD OR PharmD OR MD and relevant protein design experience


Master’s degree and 3 years of protein design experience


Bachelor’s degree and 5 years of protein design experience

Preferred Qualifications:

  • PhD in biochemistry, biophysics, computational biology, structural biology, or a related field; Relevant postdoctoral experience is a plus

  • Proven track record of successfully applying physics-based and state-of-the-art machine learning protein design and protein structure modeling tools (e.g., Rosetta, AlphaFold, ESMFold, ProteinMPNN, RFDiffusion, or similar) to solve challenging protein design problems

  • Experience working in the wet lab or directly with wet lab scientists (display technologies and/or recombinant protein production is a plus)

  • Proficiency in Python or similar programming languages

  • Experience working interactive data science environments and code repositories

  • Experience working in cloud and high-performance compute environments

  • Great communication abilities and meticulous attention to detail, including for written and oral presentation and code documentation

  • Broad general interest in protein biochemistry

  • Ability to drive an end-to-end project including working with collaborators to deliver results

  • Desire to be part of a team that transforms objectives into tangible outcomes, propels numerous dynamic projects, and cultivates effective cross-functional partnerships


What you can expect of us

As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:

  • Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.

  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

  • Stock-based long-term incentives

  • Award-winning time-off plans and bi-annual company-wide shutdowns

  • Flexible work models, including remote work arrangements, where possible

Apply now

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.