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Amgen Principal Scientist - PKDM in South San Francisco, California


If you feel like you’re part of something bigger, it’s because you are. At Amgen our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies. We are global collaborators who achieve together—researching, manufacturing and delivering ever-better products that read over 10 million patients worldwide. It’s time for a

career you can be proud of. Join us.

Principal Scientist

The department of pharmacokinetics and drug metabolism (PKDM) within Amgen Research is dedicated to the discovery and development of novel, effective, safe medicines. The successful candidate will work in a team environment to characterize the absorption, distribution, metabolism, excretion and pharmacokinetic properties of therapeutic drug candidates to achieve their full pharmacological potential. PKDM (DMPK) works in close partnership with disciplines such as pharmacology, protein sciences, medicinal chemistry, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to design promising clinical therapeutic candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.

What you will do

Let’s do this. Let’s change the world. The responsibilities of a PKDM Principal Scientist are to develop staff, lead scientific strategy across the PKDM department, and build relationship across functions within the larger Research organization. The role will require data interpretation, communication of results, and contribution to decision making on project teams as PKDM representative in support of drug discovery and development. In addition, there are opportunities and expectations to impact the external scientific community.


What we expect of you

This role requires an excellent understanding of preclinical ADME across drug modalities (e.g. monoclonal antibodies, bi-specifics, RNAi and small molecules) and the factors influencing drug disposition, as well as an individual that can work collaboratively in a highly collaborative, matrixed team environment.

Basic Qualifications

Doctorate degree and 4 years of pharmacokinetics and drug metabolism experience


Master’s degree and 7 years of pharmacokinetics and drug metabolism experience


Bachelor’s degree and 10 years of pharmacokinetics and drug metabolism experience

Preferred qualifications:

PhD or MS in biochemistry, immunology, biophysics, or equivalent

4+ years of protein therapeutics drug discovery and development experience in biotech industry, basic understanding of protein therapeutics pharmacokinetics

Expertise in multi-specific drug targeting modalities


What you can expect of us

As we work to develop treatments that take care of others, so we work to care for our teammates’ professional and personal growth and well-being.

  • Vast opportunities to learn and move up and across our global organization

  • Diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act

  • Generous Total Rewards Plan comprising health, finance and wealth, work/life balance, and career benefits

Apply now for a career that defies imagination

In our quest to serve patients above all else, Amgen is the first to imagine, and the last to doubt. Join us.

Equal Opportunity Statement

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request an accommodation.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.​