Amgen Principal Scientist - Clinical Biomarkers Oncology in South San Francisco, California
The use of Biomarkers and Diagnostics is central to understanding how our therapeutics work and identifying patients that benefit most from these therapies. Accordingly, the Clinical Biomarkers & Diagnostics function in Translational Medicine at Amgen has a critical role in advancing our drug development programs and is responsible for the delivery of biomarker development across our pipeline.
The Oncology Clinical Biomarker team is seeking a highly motivated Principal Scientist dedicated to biomarker development in Oncology. Integral to the ongoing success of Amgen’s comprehensive biomarker programs, the clinical biomarker team is responsible for developing and executing the biomarker strategy for each program by applying cutting edge, innovative technologies to advance science in support of Amgen’s mission. The successful candidate is expected to work cross-functionally within Amgen and to interact closely with groups across both clinical development and discovery research. The position will focus on the development and implementation of translational biomarker strategies to inform pharmacodynamics, mechanism of action, and patient stratification/selection in support of the progression of Amgen’s pipeline candidates from late preclinical development through all stages of clinical development. The role is responsible for developing comprehensive biomarker strategies, designing experiments, authoring and implementing protocols, executing biomarker studies, organizing data, drafting technical reports or tech transfer documents, and interpreting and communicating results to cross-functional teams.
The role is expected to work in a highly matrixed environment and drive scientific and technical innovation collaboratively with other members of the Clinical Biomarkers & Diagnostics and Translational Medicine functions, as well as with the Amgen research and development community.
Amgen employees adhere to all corporate and local guidelines and regulations related to compliance and health and safety.
Doctorate degree and 3 years scientific experience
Master’s degree and 6 years of scientific experience
Bachelor's degree and 8 years scientific experience
PhD with 5+ years industry experience developing biomarker strategies in a clinical development setting and/or in preclinical biomarker discovery/validation
Knowledge and translational biomarker experience in immuno-oncology is highly desirable
Strong background in tumor biology and cancer genomics
Clinical development experience working with cross-functional teams conducting clinical trials
Experience in developing program-based strategies for pharmacodynamic, predictive, and exploratory biomarkers
Experience implementing a broad array of biomarker platforms and technologies to support clinical-stage programs
Demonstrated ability to establish and execute biomarker studies and collaborations with academic laboratories/KOLs
Experience in assay development and qualification and analysis of clinical samples
Experience managing biomarker assay outsourcing processes with external vendors and CROs
Poise and professionalism with strong communication and influencing skills in a dynamic environment
If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.
Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.