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Amgen Executive Director, Translational Pathology in South San Francisco, California

HOW MIGHT YOU DEFY IMAGINATION?

At Amgen, every challenge is an opportunity. And every opportunity brings the potential to change lives. Our shared mission—to serve patients—has driven our status as one of the world’s preeminent biotechnology companies, reaching over 10 million patients worldwide. Leverage your high-level expertise to lead and forge partnerships that advance the biotechnical and biopharmaceutical science that can turn the tide of serious, life-interrupting illnesses.

Live

What you will do

Let’s do this. Let’s change the world. Amgen is currently offering a unique opportunity for a highly motivated individual to join our team as a Head of Development Translational Pathology, within the Clinical Biomarkers and Diagnostics Department. The Executive Director will build the Translational Pathology capability in development and will provide leadership and expertise in human disease pathology, molecular pathology, image analysis and interpretation to support the discovery, translation to human disease and clinical development of oncology biomarkers and companion diagnostics (CDx).

The Executive Director will have the opportunity to work in a highly collaborative environment and to support projects from entry into first in human through clinical development, and they will represent the Development Translational Pathology department in discussions and strategic planning, both internally and externally.

Responsibilities

  • Build the Translational Pathology capability in Development and identify the critical subject matter expertise that we need to have in-house versus outsourced

  • Implement focused and proactive biomarker and Dx strategies, including incorporation of innovative technical modalities, such as imaging

  • Present to internal decision-making committees and management on translational pathology proposals, strategies, and ongoing workflows

  • Provide pathology expertise to development project teams, and leadership, to ensure access to strategic thinking on appropriate tissue-based techniques and samples for target pathway evaluation in human disease:

  • Build internal human tissue bank and/or establish appropriate academic collaborations and CRO contracts to acquire human tissue specimens to evaluate new target expression and/or pathway activation in disease vs health

  • Implement novel technologies and/or methodologies as needed, via a combination of inhouse efforts and the use of CROs or other external expertise

  • Evaluate novel biomarkers in human disease samples via techniques such as in situ-hybridization, immunohistochemistry, IHC multiplexing, fluorescence applications, use of image analysis algorithms, laser capture microdissection, RNAseq, qPCR, etc.

  • Evaluate the scientific basis and clinical applicability of the proposed assays, their validation status, and any related technical issues

  • Assume responsibility for the assessment and scoring of specimens and the preparation of reports summarizing the data, analysis, and interpretation of findings

  • Collaborate with project teams from concept to reagent generation to quantitation and approval plan for CDx as needed

  • Lead the qualification of tissue-based biomarkers, including their characterization and validation (biomarker prevalence, clinical utility for patient selection/stratification, relevant cutoffs, etc.) and the proposed pathology assays (specificity and sensitivity, scoring system, etc.)

  • Design, implement and oversee pathology-based biomarker and diagnostic testing and data analysis for clinical development studies and associated translational research:

  • Direct the development, outsourcing and validation of clinically applicable tissue based assays

  • Assists in the development of assay protocols as needed

  • Write the relevant pathology-based biomarker and diagnostics testing sections in drug reports, investigator brochures, and regulatory submission packages (INDs, NDA’s, BLA's)

  • Participate in the evaluation of external licensing or collaborative opportunities (including CDx collaborations) and oversee internal components of shared programs

  • Present key results at group meetings, governance bodies, scientific conferences and to key internal and external stakeholders and collaborators

  • Interface with internal functions and external companies to provide technical guidance in the development of clinical biomarker assays and IVDs as needed.

Basic Qualifications

  • Doctorate degree & 6 years of clinical and/or pathology experience OR

  • Master’s degree & 10 years of clinical and/or pathology experience OR

  • Bachelor’s degree & 12 years of clinical and/or pathology experience AND

  • 6 years of managerial experience directly managing people and/or leadership experience leading teams, projects, programs or directing the allocation of resources

Preferred Qualifications

  • A PhD in Pathology from an accredited school is required

  • MD or DVM from an accredited medical school

  • Board certified in the US is desirable, but not required

  • Molecular Pathology experience with publications and experimental pathology supporting research

  • Ten years of industry or academic research

  • Experience independently leading and conducting research and ability to summarize information/data in a concise, easy to understand manner

  • Leadership skills including mentoring, motivation, and delegation

Thrive

What you can expect of us

As we work to develop treatments that take care of others, so we work to care for our teammates’ professional and personal growth and well-being.

  • Clear and disciplined strategic vision for the future that leverages superior-quality products, operational excellence, and top-shelf-talent

  • Diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act

  • Generous Total Rewards Plan comprising health, finance and wealth, work/life balance, and career benefits

Amgen’s Commitment to Our Staff

At Amgen, our mission is serving patients. Our staff are dedicated to pushing the boundaries of science to transform medicine and turn the tide on serious illnesses. Central to achieving this mission is our “people-first” philosophy. We recruit the best talent, build an environment that facilitates career growth, and provide staff with the opportunity to make significant contributions for patients and our business.

Consistent with our core leadership value of “Develops the Best Team,” we are seeking leaders that prioritize the development of talent. As a manager, your priority and primary role is to accelerate the performance and development of your team. We expect managers to exemplify strong leadership and champion self-awareness and career development Ways that you will display your leadership acumen in this role include:

  • Mentoring, coaching, and developing staff to build highly skilled, diverse, and inclusive teams

  • Fostering a positive and respectful work environment that encourages staff retention and motivates individuals to work toward common goals and priorities

  • Ensuring that staff understand how their efforts and contributions make a meaningful impact to the business

  • Growing core skills and capabilities among staff, particularly in learning agility, problem solving, strategic and creative thinking, flexibility, resilience, effective communication, prioritization, delivery of results, and continuous improvement

  • Making accurate evaluations of your team's skills and competencies and providing timely and respectful feedback, including direct delivery of difficult messages

  • Developing an understanding of your team's career objectives and serve as a thought-partner in their career development plans

  • Assisting staff with preparing for roles of growing responsibility and identifying new opportunities that expand their skills and align with their overall career objectives

  • Resolving critical gaps in the organization’s internal capabilities and skillsets, including strategic external recruiting

  • Identifying diverse, qualified successors for key positions

  • Ensuring that direct reports who also lead people consistently demonstrate these same behaviors with their staff

We understand that to successfully sustain and grow as a global enterprise and deliver for patients — we must ensure a diverse and inclusive work environment.

Our culture is what makes Amgen a special place to work. We have a powerful shared purpose around our mission – to serve patients. We respect one another, recognize contributions, and have embedded collaboration, trust, empowerment, and inclusion in all that we do.

MEANINGFUL IMPACT . To serve patients. We are all deeply committed to our mission: to serve patients. And we all have opportunities to contribute to that mission in meaningful ways. This creates a powerful sense of shared purpose.

INNOVATIVE : Stretch yourself at the cutting edge. You’re poised to have a high impact in the new Bio century, Amgen offers our people interesting and challenging work.

REPUTATION . Be behind world-renowned products and services. With our industry reputation and strong product pipeline, you can take pride in working at Amgen.

COLLABORATIVE . Work alongside the best. Be part of our highly talented, hard-working teams. Their spirit is what fuels our success.

REWARDING . Get a fair share in success. Everyone’s contribution is recognized – and strong performance is rewarded.

We equip all our staff members to live well-rounded, healthy lives. Most recently, Amgen added benefits for transgender employees and continues to pride itself on industry-leading, family-friendly offerings for families of all compositions.

Amgen focuses on areas of high unmet medical need and uses its expertise to strive for solutions that improve health outcomes and dramatically improve people’s lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world’s leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Amgen requires all staff in the United States and Puerto Rico to be vaccinated from COVID 19 as a condition of employment. In accordance with applicable law, Amgen will provide reasonable accommodations to staff members who qualify on the basis of a medical reason or a sincerely held religious belief, practice, or observance. Such accommodation may not pose an undue hardship to Amgen, its operations, or its staff.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

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