Amgen Postdoctoral Fellow – Virtual Screening for DNA-Encoded Library Technology in Copenhagen, Denmark
HOW MIGHT YOU DEFY IMAGINATION?
You’ve worked hard to earn your degree and you are now ready to take the next step in your career. How will you leverage your skills, experience, and passion to work toward your goals? At Amgen, our shared mission—to serve patients—drives all that we do. For more than four decades, Amgen has pioneered biotechnology breakthroughs to bring state-of-the-art medicines from laboratory to patients, reaching over 10 million patients worldwide. Come to do your best work alongside other innovative and driven professionals in this meaningful role.
Postdoctoral Fellow – Virtual Screening for DNA-Encoded Library Technology
Synergize Virtual Screening and DNA-encoded Library Technology for Next Generation Ligand Discovery
Let’s do this. Let’s make an impact. This is a unique opportunity to join Amgen Research Copenhagen (ARC) site as a Postdoctoral fellow. Using our DNA-Encoded Library (DEL) technology, ARC contributes significantly to Amgen’s many small-molecule drug discovery projects from hit discovery, all the way, to drug candidate selection.
In this role, you will be developing and applying Virtual Screening methodologies to sharpen the power of DEL screening and associated technologies. You will be joining a thriving and scientifically diverse ecosystem, working with the world leaders in DEL technology and in close collaboration with experts in medicinal and parallel chemistry as well as biochemistry, biophysics and biology to tackle challenging Drug Discovery programs. You will also have the opportunity to write manuscripts, publish in leading journals, and present data in internal and external settings including oral and poster presentations at scientific conferences. You will be enrolled in the Amgen postdoc program and be part of the Amgen Research postdoc community interacting with fellow postdocs across our research organization.
The postdoctoral fellow will have two co-mentors who lead Amgen’s Copenhagen site Structural-Based Drug Discovery and Research Informatics efforts, respectively.
The postdoctoral fellow will:
Develop Virtual Screening methods enabling two-way synergy with the DEL screening technology
Apply DEL screening data insights to enhance virtual small molecule ligand discovery for specific targets
Explore new paradigms of fragment combination screening within synthetically feasible chemical space
Investigate the current capabilities of ligand-binding determination and define new standards and state-of-the-art workflows within the field
The post doc will report to Scientific Director, and leader of the ARC Research Informatics group, Mads Nørregaard-Madsen and mentored by Research Scientist Loris Moretti. For further information contact: HR Manager Helena Pechter (firstname.lastname@example.org)
WHAT WE EXPECT OF YOU
We are all different, yet we all use our unique contributions to serve patients. The Scientist professional we seek is an innovative leader with these qualifications.
- PhD in a computational chemistry, biophysics, or other related fields
- PhD in chemistry combined with at least 3 years postdoc level experience in relevant computation science fields
Solid understanding of structure, properties, and interactions of molecules
Experience with structural biology and molecular modeling, with methods such as docking, and structure- and ligand-based screening
Knowledge about Molecular Dynamics and Quantum Mechanics applications relevant to drug discovery
Knowledge of advanced machine learning methods and their applications to computational chemistry/modelling
Proficiency in Python or other programming/scripting languages
Experience working in Linux-shell based environment and high-performance computing environments
Good communicator, able to write and speak about technical concepts to various kind of audiences
Proficiency in written and spoken English
Able to work independently, driving ideas forward from initiation to closure
SOME OF THE REWARDS OF WORKING HERE
As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being.
Full support and career-development resources to expand your skills, enhance your expertise, and maximize your potential along your career journey
A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act
Generous Total Rewards Plan—comprising health, finance, work/life balance and other benefits
Please note that the position is at our Copenhagen research site and therefore it is required to have or be eligible to obtain a permit to live and work in Denmark. All applications and contacts are confidential. Candidates should apply as soon as possible since the selection will start shortly.
If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.
Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney diseases, rheumatoid arthritis and other serious illnesses.
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.