Amgen Sr. Associate Scientist - Pharmacokinetics and Drug Metabolism in Cambridge, Massachusetts
Amgen (NASDAQ:AMGN), a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses. With a deep and broad pipeline of potential new medicines, we continue to advance science to serve patients.
Amgen is seeking a highly motivated Senior Associate Scientist to join the Pharmacokinetics & Drug Metabolism (PKDM) department at our Kendall Square site in Cambridge, Massachusetts.
In this role, you will add scientific expertise to the discovery and non-clinical development of small molecule therapeutics by carrying out in vitro ADME assays with a primary focus on drug transporters. You will be primarily responsible for establishing, optimizing and trouble-shooting transporter screening assays to evaluate new chemical entities as substrates or inhibitors of drug transporters. You will also be contributing to the investigative work aimed towards improving our understanding of the role of drug transporters as they relate to absorption, distribution, and clearance of small molecule therapeutics.
In this position your core responsibilities are to:
Plan, conduct, analyze, interpret, and communicate results generated from transporter studies.
Independently design and execute transporter and potentially other in vitro ADME studies which may include screening as well as mechanistic studies.
Evaluate and implement emerging in vitro and in silico tools to support the prediction of transporter-mediated pharmacokinetics (PK) and drug interactions (DDIs) in humans.
Design and complete IND and NDA-enabling studies and report writing to support regulatory submissions. Additionally, you may have the opportunity to interact with contract research organizations (CROs).
Contribute to the implementation of new assays/techniques based on portfolio needs. Opportunities will be available to contribute to evaluation of cutting edge technology emerging in the field to provide answers to ADMET questions.
Your specific contributions will depend on your expertise, interests, training, and experience. You will also have opportunities to learn and obtain experience with PKDM strategies for the discovery and non-clinical development of multiple therapeutic modalities.
A collaborative and highly capable scientific community at Amgen is available to support these efforts. Interactions and collaborations with academic and other external scientists are encouraged.
Master’s degree and 3 years Scientific experience
Bachelor’s degree and 5 years Scientific experience
Experience in transporter assays and cell culture handling
Experience with TECAN automation, mass-spectrometry based and radiometric analysis
Experience in drug discovery and/or development programs; expertise with implementing, optimizing and troubleshooting in vitro transporter assays; and demonstrated ability to communicate with team members across broad disciplines and geographical locations.
Effective oral and written communication skills
Our culture is what makes Amgen a special place to work. We have a powerful shared purpose around our mission – to serve patients. We respect one another, recognize contributions, and have embedded collaboration, trust, empowerment and inclusion in all that we do.