Amgen Senior Associate Scientist - Pharmacokinetics and Drug Metabolism (PKDM) in Cambridge, Massachusetts
Amgen is seeking a Senior Associate Scientist to join the Pharmacokinetics and Drug Metabolism (PKDM) department at our Kendall Square site in Cambridge, Massachusetts.
In this role, you will join a motivated team of scientists contributing to Amgen’s diverse discovery and development portfolio of therapeutic modalities with a focus on evaluating the absorption, distribution, metabolism and elimination (ADME) properties of small molecule therapeutic candidates. You will routinely interface with PKDM and therapeutic area colleagues across multiple Amgen research sites (Cambridge, MA, San Francisco, CA and Thousand Oaks, CA) to influence all stages of our drug discovery efforts, from early screening through IND-filing and beyond. In addition, the position will involve making innovative contributions to the fundamental understanding of drug biodistribution for small molecule and protein therapeutic modalities.
Core responsibilities of this position:
Conduct and optimize in vitro ADME studies that evaluate metabolic stability (microsomes and hepatocytes), protein binding (plasma and various tissue matrices), and drug-drug interaction potential (P450 inhibition and induction) of small molecule therapeutic candidates
Utilize appropriate cell culture techniques to support in vitro ADME, biodistribution (including use of microfluidic devices) and drug target characterization efforts
Perform mass spectrometry-based bioanalysis in support of in vitro ADME studies
Analyze, interpret and report preclinical ADME data
Beyond the core responsibilities, the successful candidate will have the opportunity to explore mechanistic inquiries into the fundamental physiological and biochemical factors that determine the ADME characteristics of small molecule and protein therapeutics. Interactions with colleagues in our multiple therapeutic areas or in the external scientific community will be highly encouraged.
Master’s degree and 3 years of research experience
Bachelor’s degree and 5 years of research experience
Master’s degree in a pharmaceutical, chemical, or biological field of study
5+ years of drug discovery and/or development experience
Expertise with implementing, optimizing and troubleshooting in vitro ADME assays
Experience with cell culture techniques
Working knowledge of multiple bioanalytical platforms (mass spectrometry) is a plus.
Critical thinking and demonstrated ability to effectively communicate with team members
Effective oral and written communication skills
Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing, and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology. Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people’s lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world’s leading independent biotechnology companies, has reached millions of patients around the world, and is developing a pipeline of medicines with breakaway potential.
Our culture is what makes Amgen a special place to work. We have a powerful shared purpose around our mission – to serve patients. We respect one another, recognize contributions, and have embedded collaboration, trust, empowerment and inclusion in all that we do.