Amgen Biochemist in predictive safety in Cambridge, Massachusetts
As part of our commitment to bring safe and transformative medicines to patients, we are growing our innovative Translational Systems Biology group at Amgen. Our mission is to ensure that the drugs we develop are safe.
To achieve this we are applying a variety of human-focused in vitro approaches, including biochemistry, omics techniques, human genetics, molecular and cellular biology to develop assays that can predict or elucidate mechanisms leading to drug safety issues. In addition to working broadly to support pipeline projects, we are also developing novel platform for assessing the safety of our drug targets in human systems with the long-term goal of being able to focus our future regulatory studies in this area.
Amgen is seeking a Scientist with expertise in biochemistry and proteomics to join our group to work out of their Cambridge, MA location.
The responsibilities of the Scientist position include:
Taking a leading role to biomarker strategy, discovery and development utilizing modern biochemical and molecular approach
Design and perform fit for purpose experiments to understand molecular mechanism of drug adverse effects to support safety prediction
Apply scientific and technical background in assay development and qualification across multiple platforms
Evaluate the implementation of new platforms and collaborations to advance safety assessment
Work in a highly diverse and integrated environment and mentor junior scientists
Proactively engage in issue resolution and deliver high quality data in a timely manner
Able to perform mega data analysis, interpretation and presentation
Prepare, review and deliver scientific presentations internally and externally
Master's degree and 4 years of scientific experience
Bachelor's degree and 6 years of Scientific experience
2+ years of postdoctoral experience with a focus on proteomics and biochemistry
Experience in biochemistry, protein chemistry, pharmacology, or molecular biology
Strong laboratory experience in biomarker or target discovery/validation with expertise in high sensitivity protein and/or nucleic acid based platforms
Experience in resolving experimental questions through design and application of both traditional and innovative scientific and technical approaches (mass spectrometry-based biomarker discovery; imaging)
Experience in field of immune-oncology and neurology
Demonstration of scientific excellence, curiosity, proactivity, critical thinking and review
Thrive within change, highly adaptable and embrace new challenges with a positive attitude
Scientifically nimble, multipurpose and adaptable
Inspired by innovation and out-of-the-box thinking
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.