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Amgen Principal Scientist – Protein Technologies Team Lead in Burnaby, British Columbia


If you feel like you’re part of something bigger, it’s because you are. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies. We are global collaborators who achieve together—researching, manufacturing, and delivering ever-better products that reach over 10 million patients worldwide. It’s time for a career you can be proud of. Join us.

Principal Scientist


What you will do

Let’s do this. Let’s change the world.

Amgen’s Therapeutic Discovery organization is seeking an enthusiastic, collaborative Principal Scientist team lead to join the Protein Technologies group at our Amgen British Columbia site. Protein Technologies is responsible for designing, planning and executing on the generation of key enabling DNA and protein reagents to support discovery of small and large molecule therapeutics and cutting-edge novel modalities.

As a team lead within Protein Technologies, you will be responsible for managing a high-performing team with a mandate to produce high quality reagents to support the Amgen pipeline. You will be responsible for the operational, strategic, and scientific management of the group and will also actively participate in the science through hands-on lab work and implementation of enabling technologies and automation. You will also be responsible for aligning with our Protein Technologies group in South San Francisco and for initiating and driving collaborations with partner functions such as Antibody Discovery, Therapeutic Areas, and Molecular Structure.

Well-suited applicants will have a strong scientific background in recombinant protein expression, purification, and analytics, a deep scientific curiosity, and demonstrated success in project and personnel management.


What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The Protein Scientist we seek is a highly motivated leader with these qualifications.

Basic Qualifications

Ph.D. in Biochemistry, Biophysics, Chemistry, Molecular Biology, or a related discipline and 3 years of industry experience

Preferred Qualifications

  • Ph.D. and postdoc from a leading institution or biotechnology company with 5+ years of related industry experience

  • A track record of scientific accomplishments and project leadership in biologics drug development as evidenced by peer-reviewed publications, patents, or pipeline contributions

  • 3+ years of managing a high-performing team in industry with a focus on protein expression, purification, and analytics

  • Expertise in recombinant protein expression in transient and stable mammalian hosts such as HEK293 and CHO

  • Expertise in purifying a range of different protein types (e.g. extracellular domains, glycoproteins, monoclonal and multi-specific antibodies, membrane proteins) using multiple chromatographic methods (e.g. affinity, ion exchange, size exclusion, hydrophobic interaction chromatography)

  • Expertise in protein analytics, including HPLC-SEC and LC-MS is preferred

  • Experience with increasing productivity through automation is preferred

  • Microbial protein expression experience is preferred

  • Familiarity with processes in antibody discovery

  • Strong written and verbal communication and interpersonal skills

  • Ability to inspire and grow a high-performing team, chart and set team goals into action, and forge productive cross-site collaborations with partner functions


What you can expect of us

As we work to develop treatments that take care of others, so we work to care for our teammates’ professional and personal growth and well-being.

  • Vast opportunities to learn and move up and across our global organization

  • Diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act

  • Generous Total Rewards Plan comprising health, finance and wealth, work/life balance, and career benefits

Apply now for a career that defies imagination

In our quest to serve patients above all else, Amgen is the first to imagine, and the last to doubt. Join us.

Equal Opportunity Statement

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request an accommodation.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.