Amgen Jobshttp://www.amgen.jobs2012-05-27 01:22:27.074783USASeattleAuto req 15679BR Job Posting Title Sr Associate (Purification) Career Category Process Development Employee Subgroup Hourly FT Country (State/Region) United States - Washington Location (City) Seattle Amgen Job Description The candidate will be a member of the Purification Process Development (PPD) department. Candidate will be part of a technical team involved in product recovery and purification process development of monoclonal antibodies and other proteins. Work will involve bench and pilot scale process and technology development activities in the areas of harvest clarification, chromatography, and/or filtration. Technology transfer to pilot, clinical and commercial manufacturing as well as data documentation will be aspects of this job. Basic Qualifications - Master’s degree, or will have obtained degree by August 2012 OR - Bachelor’s degree & 2 years of directly related experience OR - Associate’s degree & 6 years of directly related experience OR - High school diploma / GED & 8 years of directly related experience Preferred Qualifications - Master’s degree in Biochemistry, Chemical Engineering or scientific field OR - BS in Biochemistry, Chemical Engineering or scientific field and 3+ years in purification process development - Experience in product recovery/clarification, chromatography, filtration, and/or high throughput screening (HTS) technologies - Experience in developing purification processes for clinical and/or commercial manufacturing - Ability to work well in a team environment - Excellence in communication skills – both verbal and written2012-05-13 20:34:33United StatesAmgenWashington15679BRWASeattle, WA28663965http://www.amgen.jobs/xml/28663965/jobUSASeattleAuto req 14549BR Job Posting Title Sr Scientist - Bioinformatician / Computational Biologist Career Category Scientific Employee Subgroup Salaried FT Country (State/Region) United States - Washington Location (City) Seattle Amgen Job Description The Department of Comparative Biology and Safety Sciences is looking for a highly motivated bioinformatician/computational biologist to contribute to its programs for toxicity screening and hazard identification in preclinical drug development. The successful employee will develop and utilize a variety of analytical approaches and computational tools to help integrate and analyze high volume data sets, including omics, next-gen sequencing, mass spectrometry, and selectivity data. In this position, the individual is expected to proactively support and lead selected projects. The employee will be responsible for enhancing in-house bioinformatics tools and databases and developing new methodologies for complex data analysis and visualization. Data integration, management, and visualization are anticipated to be a substantial component of this job and the employee is expected to provide leadership and expertise in these areas. An excellent team spirit, proactive attitude, and good communication skills are necessary. Basic Qualifications Doctorate degree & 2 years of scientific experience OR Master’s degree & 8 years of scientific experience OR Bachelor’s degree & 10 years of scientific experience Preferred Qualifications A PhD in Bioinformatics, Mathematics, Computer Science, Physical Sciences, or related fields with 3+ year working experience in biomedical environment is required. A strong knowledge in mathematical modeling, statistical analysis, and relational databases are expected. Proven track record of integrating and analyzing various types of large-scale biomedical data as well as omics data are essential. Ability to translate biological questions into computational work streams and the ability to translate the outcome of computational processes into biologically meaningful messages are highly desirable. Skills in algorithm development as well as high level scripting languages such as R, Matlab, or S+ are also expected. Software engineering experience in a team environment is a plus. A proven ability and willingness to work with multidisciplinary teams is essential. Strong written and oral communication skills, self-motivation, independence and leadership are required. Prior experience of drug discovery and development process and knowledge of technology platforms are preferred, but not required.2012-03-27 20:14:32United StatesAmgenWashington14549BRWASeattle, WA27423835http://www.amgen.jobs/xml/27423835/jobUSASeattleAuto req 14024BR Job Posting Title Post Doctoral Fellow - Functional Biocharacterization Career Category Process Development Employee Subgroup Salaried FT Country (State/Region) United States - Washington Location (City) Seattle Amgen Job Description We are seeking a highly motivated, creative postdoctoral fellow to investigate and develop approaches for assessing Fc-mediated effector functions of therapeutic monoclonal antibodies. The project will require extensive cellular and molecular biology including the development and use of in vitro cell-based assay systems and in vivo animal models. Basic Qualifications This position requires a Ph.D. in immunology, cell biology, molecular biology, or related field. Ph.D. must be awarded before the start of the post doctoral position. Preferred Qualifications The candidate must have excellent cell culture, cell biology, molecular biology, and analytical skills as well as a good understanding of antibody Fc effector functions. The candidate must be highly self-motivated, have excellent communication skills (oral and written), and the ability to work independently and in a multidisciplinary team environment.2012-03-14 03:14:26United StatesAmgenWashington14024BRWASeattle, WA27126957http://www.amgen.jobs/xml/27126957/jobUSASeattleAuto req 14154BR Job Posting Title Director Preclinical (Quantitative Pharmacology/PKDM) Career Category Clinical Development Employee Subgroup Salaried FT Country (State/Region) United States - Washington Location (City) Seattle Amgen Job Description Amgen, Inc. is seeking a highly motivated candidate for the position of Director in the Quantitative Pharmacology Group of the PKDM Department. The Director will provide strategic vision and portfolio leadership in support of small and large molecule drug development, registration, and/or post-marketing activities. He/she will be responsible for portfolio-level strategic and resource planning, communication, scientific/technical deliverables, and issue resolution. A key focus will be to serve as functional representation for Amgen internal governance reviews and external scientific and regulatory communities including face-to-face interactions with global regulatory/health authorities. The individual will interface with internal business stakeholders (such as Research, Toxicology, Early Development, Clinical Development, Biostatistics, CMC, Regulatory Affairs, etc.). The candidate will mentor and advise a group of project team representatives at all stages of discovery and clinical development and implement advanced modeling & simulation (M&S) strategies across the portfolio to influence decision making. The individual will be responsible for the development of key operational efficiencies and new technologies within the quantitative pharmacology group. Basic Qualifications - Doctorate degree & 7 years of scientific experience Preferred Qualifications - PhD in Pharmacokinetics, Pharmaceutical Sciences, or with equivalent professional degrees (e.g. MD, PharmD) with 10 years experience in the Biotechnology/Pharmaceutical Industry or post-doctoral training - Experience as PKDM/Clinical Pharmacology functional representative on product development teams - Experience with PK and PK/PD data analysis, interpretation, and reporting for small molecule and/or protein therapeutics - Hands-on experiences in population PK/PD modeling and simulations (M&S) - Experience in authoring regulatory documentations (IND, IMPD, CTX, RTQ, CTD, etc), knowledge in global regulatory requirement and guidance, and interaction with global health authorities - R&D experience in oncology therapeutics, inflammation and/or metabolic therapeutic areas - Leadership quality for effective team building with strong decision making and problem solving skills - Excellent interpersonal, technical, and communication skills to lead a group of quantitative pharmacology scientists - Excellent problem scoping, planning and business skills necessary to drive decision making and influence senior leadership - Project management skills for timeline tracking and resource planning - Solid publication record as senior author and growing reputation with external peers. - The successful candidate will have strong interpersonal communication and leadership skills.2012-02-29 22:30:57United StatesAmgenWashington14154BRWASeattle, WA26849234http://www.amgen.jobs/xml/26849234/jobUSASeattleAuto req 13373BR Job Posting Title Scientist - Biotech Engineering Career Category Operations Employee Subgroup Salaried FT Country (State/Region) United States - Washington Location (City) Seattle Amgen Job Description A Scientist would be expected to act as a lead technical support for a pre-commercial drug product program within process development to achieve the resolution of technical issues, to author technical documents and support all technical issues around commercialization of the drug product. Support of technology transfer and site selection, equipment selection, process design, validation strategy, and relevant GMP documentation is also required. The scientist applies fundamental scientific (biochemistry, biophysics, statistics, etc.) and engineering principles to resolve processing issues and develop a robust commercial product, as well as evaluating changes such as process improvements, equipment, scale, and raw materials Participate as author for process transfer documentation, technical reports, batch records, GMP documentation and regulatory filings. Travel will be required. Basic Qualifications • Doctorate degree OR • Master’s degree & 3 years of directly related experience OR • Bachelor’s degree & 5 years of directly related experience OR • Associate’s degree & 10 years of directly related experience OR • High school diploma / GED & 12 years of directly related experience Preferred Qualifications Ph.D. in Chemical Engineering, Biochemical Engineering, Pharmaceutical Sciences or Life Sciences. 4+ years of relevant biotech experience in process development within a pharmaceutical or biotechnology corporation. Ability to apply fundamental scientific (biochemistry, biophysics, statistics, etc.) and engineering principles to develop the drug product process, troubleshoot manufacturing operations, evaluate equipment design, and scale up the drug product process. Experience with process development for biologics including lyophilization cycle development. Experience participating in global, cross-functional teams working on technology transfer of biologics.2012-02-08 02:38:38United StatesAmgenWashington13373BRWASeattle, WA26389646http://www.amgen.jobs/xml/26389646/job