Amgen Jobshttp://www.amgen.jobs2012-05-27 00:52:50.041734USAThousand OaksAuto req 15647BR Job Posting Title Scientist (Cell Sciences & Technology) Career Category Process Development Employee Subgroup Salaried FT Country (State/Region) United States - California Location (City) Thousand Oaks Amgen Job Description This position is for an entry level scientist that will be involved in cell culture process development in support of pipeline molecules. The successful candidate will play a key role in leading and supporting various project teams. Aside from process optimization, the work will frequently involve scale-up of bioreactors and transfer of processes to pilot plant and cGMP manufacturing facilities. The individual will also be responsible for advancing process technology and proprietary cell culture medium in order to improve productivity and efficiency, and control desirable product quality. The person will also be expected to play a technical leadership role in the department for various technology development initiatives in the organization. Needs to be very hands-on with all scales of cell culture operation from plate to shake flask to bioreactors. Will often conduct independent research studies and be expected as a self-starter of research projects. Must consistently keep up-to-date of scientific publications in order to incorporate new scientific understanding and technology into development work. This person will also author technical reports and publications on a routine basis. Basic Qualifications - Doctorate degree OR - Master’s degree & 6 years of scientific experience OR - Bachelor’s degree & 8 years of scientific experience Preferred Qualifications - Ph.D. in chemical engineering, biochemical engineering, bioengineering or biochemistry; some experience post Ph.D. in a postdoctoral research or industrial setting is desirable - Must be familiar with mammalian cell culture in the context of process development such as host cell engineering, transfection, stable cell line generation, clone selection, medium development, bioreactor design, optimizing productivity, and characterization using different modes of reactor operation - Knowledge of cellular metabolism and glycosylation, molecular cloning techniques, assay development for understanding cellular mechanisms, and high-throughput cell culture technology are strongly desired - Ability to use various statistical methods to analyze and interpret data is critical. - Need to have strong project management and organizational skills2012-05-08 18:42:31United StatesAmgenCalifornia15647BRCAThousand Oaks, CA28541276http://www.amgen.jobs/xml/28541276/jobUSAThousand OaksAuto req 15418BR Job Posting Title Scientist (Cell Sciences & Technology) Career Category Process Development Employee Subgroup Salaried FT Country (State/Region) United States - California Location (City) Thousand Oaks Amgen Job Description The Cell Science and Technology department is recruiting a Scientist (PhD.) level researcher within the cell line development and engineering functional area. The successful candidate will become a key member of a team focused upon the development of production cell lines for Amgen's large molecule biotherapeutic pipeline. The successful candidate will help direct lab personnel in both cell line and technology development programs. This team member will work towards the continued development of new, cutting-edge technologies to enhance outcomes and improve current scientific understanding, directed towards improving production cell line development and performance; with yield, speed, and efficiency in mind. The Scientist will enhance and improve established platform approaches and utilize solid problem solving skills as well as out-of-the-box thinking to deliver technology improvements. Basic Qualifications - Doctorate degree (or finalizing PhD by July 2012) OR - Master’s degree & 6 years of scientific experience OR - Bachelor’s degree & 8 years of scientific experience Preferred Qualifications - Ph.D. in molecular / cell biology or associated life science, combined with experience related to or directly applicable to bioprocess development and cell line generation. - Strong molecular biology skills are essential together with expertise in mammalian cell culture, in particular stable cell line generation and clone screening. - Expertise in transcriptomics or similar ‘omics’ technologies and/or current gene knockout technologies highly advantageous. - Proven interdisciplinary project management skills - A track record in resolving and overcoming issues associated with the cell line development process and associated technologies - Recognized in the scientific community through a record of publications and/or patents - Previous experience in the biotechnology area related to bioprocess and cell line development - Solid scientific understanding of cell line development and associated technologies - Strong mentoring capabilities, data driven decision-making and project management skills to help drive the team towards new performance levels. - Demonstrated independence, innovation and a strong track record of success2012-04-19 20:53:40United StatesAmgenCalifornia15418BRCAThousand Oaks, CA28013402http://www.amgen.jobs/xml/28013402/jobUSAThousand OaksAuto req 15369BR Job Posting Title Sr Scientist (Cell Sciences) Career Category Process Development Employee Subgroup Salaried FT Country (State/Region) United States - California Location (City) Thousand Oaks Amgen Job Description Seeking a highly motivated and independent individual that will lead a team responsible for the development, optimization, scale-up and transfer of mammalian cell culture processes to support early and late stage pipeline projects. Lead the overall strategy in the planning, design and execution of experiments that successfully meet project timelines and goals. Need to be very hands-on with bioprocess operation and adept in resolving equipment issues. Work cross-functionally with various groups such as analytical science, purification, pilot plant, and process engineering to leverage resource and support to efficiently and effectively deliver on project milestones. Author development reports, regulatory filings, and scientific publications. Champion and implement continual improvements to the cell culture platform process. Explore, develop, and implement new cutting-edge cell culture technology that can significantly improve development efficiency, process productivity, and reduce cost. Act as a scientific resource for the department and for junior members of the group. Ability to initiate, influence, and lead new scientific projects with clear scope to successful completion. Keep up-to-date with the current trends of technology and abreast of scientific publications. Basic Qualifications - Doctorate degree & 2 years of scientific experience OR - Master’s degree & 8 years of scientific experience OR - Bachelor’s degree & 10 years of scientific experience Preferred Qualifications - Ph.D. in chemical engineering, biochemical engineering, bioengineering or biochemistry - 3+ years experience post Ph.D. in a bioprocess development industrial environment - Knowledge of license applications and the drug development process - Familiar with all aspects of cell culture process development including clone screening, bioreactor optimization, medium development, scale-up and process transfer - Need to have worked with small-scale bioreactor models, single-use bioreactors, disposables, high-throughput technology, and had experience supporting GMP manufacturing and troubleshooting large-scale production - Deep understanding of cell biology, metabolism, product quality attribute effect is strongly desired - Routine use of statistical modeling and analysis of experimental data is required. Knowledge of VBA for Excel is desired. - Managerial experience of progressively increased scope - Strong project management and interpersonal skills2012-04-18 18:41:30United StatesAmgenCalifornia15369BRCAThousand Oaks, CA27978714http://www.amgen.jobs/xml/27978714/jobUSAThousand OaksAuto req 13086BR Job Posting Title Sr Scientist - Cell Sciences & Technology Career Category Process Development Employee Subgroup Salaried FT Country (State/Region) United States - California Location (City) Thousand Oaks Amgen Job Description The Cell Science and Technology department is recruiting a Senior Scientist level researcher within the cell line development and engineering functional area. The successful candidate will become a key member of a team focused upon the development of production cell lines for Amgen's large molecule biotherapeutic pipeline. The successful candidate will help direct lab personnel in both cell line and technology development programs. This team member will work towards the continued development of new, cutting-edge technologies to enhance outcomes and improve current scientific understanding, directed towards improving production cell line development and performance; with yield, speed, and efficiency in mind. The Senior Scientist will enhance and improve established platform approaches and utilize solid problem solving skills as well as out-of-the-box thinking to deliver technology improvements. Basic Qualifications - Doctorate degree & 2 years of scientific experience OR - Master’s degree & 8 years of scientific experience OR - Bachelor’s degree & 10 years of scientific experience Preferred Qualifications Candidates will require a solid scientific understanding of cell line development and associated technologies. Candidates will require strong mentoring capabilities, data driven decision-making and project management skills to help drive the team towards new performance levels. It is highly desirable that candidates with demonstrated independence, innovation, some previous bioprocess experience and a strong track record apply for this position. To be successful in this role, candidates should possess: - Ph.D. in molecular / cell biology or associated life science, combined with a minimum of 3+ years postdoctoral experience in a bioprocess development role or similar environment. - Strong molecular biology skills are essential together with expertise in mammalian cell culture, in particular stable cell line generation and clone screening. - Expertise in transcriptomics or similar ‘omics’ technologies and/or current gene knockout technologies highly advantageous. - Proven interdisciplinary project management skills - Ability to effectively mentor, motivate and manage more junior staff - previous FTE management experience essential - A track record in resolving and overcoming issues associated with the cell line development process and associated technologies - Recognized in the scientific community through a sustained record of publications and/or patents - Previous experience in the biotechnology/pharmaceutical required.2012-02-24 04:09:09United StatesAmgenCalifornia13086BRCAThousand Oaks, CA26721437http://www.amgen.jobs/xml/26721437/jobUSAThousand OaksAuto req 14010BR Job Posting Title Post Doctoral Fellow - Protein Mass Spectrometry Career Category Process Development Employee Subgroup Salaried FT Country (State/Region) United States - California Location (City) Thousand Oaks Amgen Job Description Amgen Process & Product Development is seeking a postdoctoral fellow for developing and applying hydrogen/deuterium exchange (HDX) related technologies for protein product development. The duration of the fellowship is 2-3 years, with at least two years of commitment. The successful candidate will work with a cross-site team to develop mass spectrometry (MS)-based HDX methodologies for routine use, and apply these methodologies for product-development issues such as protein folding and aggregation. Primary responsibilities for this position include a) developing a robust and user-friendly LC/MS-based HDX platform for collecting and analyzing HDX-MS data; b) applying the platform for product development related issues such as conformation stability of different protein isomers, mechanism of protein aggregation, etc.; c) transferring the developed technologies to other Amgen labs; and d) exploring other HDX technologies such as FTIR, particularly data analysis tools. The project will include a collaboration effort and require travel to the other Amgen site in Seattle, WA. The candidate will write scientific articles about the developed technologies and their applications, as well as any significant discoveries from these technologies. The candidate should be experienced in protein mass spectrometry, and have excellent writing and communication skills. Basic Qualifications This position requires a PhD and experience in protein mass spectrometry. PhD must be awarded before the start of the post doctoral position. Preferred Qualifications Experience in MS-based HDX is preferred, and experience with protein FTIR or NMR is a plus.2012-02-22 20:27:33United StatesAmgenCalifornia14010BRCAThousand Oaks, CA26687723http://www.amgen.jobs/xml/26687723/jobUSAThousand OaksAuto req 13787BR Job Posting Title Sr Associate Scientist Career Category Process Development Employee Subgroup Salaried FT Country (State/Region) United States - California Location (City) Thousand Oaks Amgen Job Description Seeking a highly motivated individual to function as a member of a commercial (drug product) process development team, focused on providing support to technology transfers, process characterization and commercial manufacturing. Position will perform experiments, organize data and analyze results with minimal supervision. Evaluation of product impact due to process variables will be a critical deliverables for this role. Understanding of degradation mechanisms for biologics, analytical methods, laboratory practices, and basic statistical methods is a need for this role. The position will establish the experimental design, develop and implement protocols, obtain reproducible and reliable results, and communicate data to the cross functional group. Experience with root cause analysis and technical investigations in the fill/finish area is a plus. Cross functional teamwork will be a critical component of this job. Regular interactions with Quality and Regulatory functions are expectations for this role. Effective communication skill is a requirement with the ability to exert influence a plus for this role. Basic Qualifications • Doctorate degree OR • Master’s degree & 3 years of directly related experience OR • Bachelor’s degree & 5 years of directly related experience OR • Associate’s degree & 10 years of directly related experience OR • High school diploma / GED & 12 years of directly related experience Preferred Qualifications • Ph.D. in Chemical Engineering, Biochemical Engineering, Biotechnology, Pharmaceutical Sciences or related field. • 2+ years experience within the pharmaceutical/biotechnology industry; Experience to include understanding of physical / chemical stability of proteins, and interpreting results from various analytical methods on proteins. Process characterization, scale-up, and/or technology transfer experience. • Experience in a matrix team environment and interacting with Analytical Sciences, Process Development, Project Management, Manufacturing, Regulatory, Compliance, and Quality. • Familiarity with cGMPs, regulatory filings and compliance issues for sterile injectable products manufactured by aseptic processing.2012-02-17 19:41:02United StatesAmgenCalifornia13787BRCAThousand Oaks, CA26597058http://www.amgen.jobs/xml/26597058/job