Amgen Principal Scientist- Mammalian Expression in Thousand Oaks, California

The Biologics department is seeking a highly motivated Principal Scientist to lead the mammalian expression group in Biologics Optimization at our state-of-the-art research facility at the Amgen headquarters campus located in Thousand Oaks, CA.

The Biologics Optimization group is responsible for the optimization, production, assessment, and selection of large molecule therapeutic drug candidates. The Principal Scientist will be a part of a multidisciplinary team with capabilities in molecular design, protein engineering, cloning, expression and purification of therapeutic protein candidates.


Scientific leadership, championing innovative methods to support and improve mammalian expression technologies and bioprocess, facilitating the development of automation solutions for expression workflows, and enabling technologies to improve expression levels and outcomes as well as the ability to lead an efficient and productive team, solve technical problems, and work both independently and in cross-functional teams.

Basic Qualifications:

Doctorate degree and 3 years of scientific experience


Master's degree and 6 years of scientific experience


Bachelor's degree and 8 years of scientific experience

Preferred Qualifications:

Ph.D. and 7+ years of biotech/pharma industry experience with emphasis on protein expression and production, especially with common mammalian transient and stable platforms as well as production/fermentation in WAVE reactors or other disposable reactor technologies.

Strong knowledge of cell biology, expression construct design, cell engineering and expression strategies for broad classes of proteins.

Understanding of protein engineering and protein biophysical properties that relate to molecule stability and posttranslational modifications.

Experience with automated liquid handling platforms and high throughput and high content assays.

Proven experience with data mining from complex data sets of biological readouts to gain new insights. Familiarity with DOE methods.

Experience in managing laboratory staff.

Strong communication and interpersonal skills, and the ability to work flexibly in a dynamic and collaborative environment.

Demonstrated a strong track record of independent critical thinking and scientific achievement in research, exemplified by publications in highly regarded journals, conference presentations or generation of intellectual property.

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.

Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.