Amgen Scientist - Protein Engineering and Design in South San Francisco, California

Amgen's Therapeutic Discovery organization is seeking an enthusiastic Scientist to join our Structure-Based Protein Engineering group within Protein Technologies. Protein Technologies is a group tasked with designing, planning, and executing on the generation of key enabling reagents required to support early discovery of small and large molecule drugs and cutting-edge novel modalities. The Structure-Based Protein Engineering group prosecutes on challenging targets and tool antibodies/cytokines requiring structural consideration and/or engineering. The work in our group involves a blend of structure analysis and computational modeling, protein design/stabilization, and experimental protein biochemistry.


Execute on protein engineering projects rapidly and effectively using a combination of structure-based engineering techniques including computational protein design. Generate and characterize designed proteins.

Continually develop and evaluate new technologies related to protein engineering.

Participate in project teams and communicate effectively with team members throughout the organization.

Work closely with the therapeutic areas, particularly oncology/inflammation and cardiometabolic disorders, to develop project-specific protein engineering strategies to support early discovery-stage projects.

Basic Qualifications

Doctorate degree


Master's Degree and 4 years of scientific experience


Bachelor's Degree and 6 years of scientific experience

Preferred Qualifications

Ph.D. and postdoc from a leading institution or biotechnology company.

Published record of excellence in protein engineering; broad knowledge of protein engineering strategies.

Strong understanding of protein structure and protein structure visualization using PyMol.

Experience in protein modeling/design using Rosetta or a similar tool.

Track-record of productive biochemical laboratory experience including cloning, protein expression (bacterial and/or mammalian), protein purification, and/or biophysical characterization.

Experience in scripting (e.g. Python, Perl), working in a Unix/Linux environment, and the analysis of biological data sets a plus.

Track-record of solving challenging technical problems independently and creatively as evidenced by publication in leading journals.

Strong written and verbal communication and interpersonal skills

Desire to be a team player and to contribute to a fast-paced cross-functional team environment

A Fortune 150 company operating in nearly 100 countries around the world, we invest in highly skilled, dedicated and collaborative individuals who are ready to contribute to our mission in meaningful ways and make a difference in the lives of our patients. That's why, as a member of our cross functional, cross discipline team, we provide you with valuable opportunities to broaden your experience and maximize your potential. Focused on the industry's most

compelling scientific discoveries and housed within industry leading facilities within the heart of the world's leading biotechnology hub, our colleagues are growing our pipeline through groundbreaking innovations. We believe in rewarding those who do rewarding work and are committed to providing careers that can help turn the tide of serious, life interrupting illnesses.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.