Amgen Scientist - Pharmacokinetics & Drug Metabolism in South San Francisco, California
Amgen is seeking a Scientist of Pharmacokinetics & Drug Metabolism. This position is located in Amgen's South San Francisco location.
The department of Pharmacokinetics & Drug Metabolism (PKDM) within Amgen is dedicated to the discovery and development of safe and effective medicines by elucidating the absorption, distribution, metabolism, excretion and pharmacokinetic properties of novel therapeutic drug candidates to improve their pharmacological potential.
PKDM works in close partnership with disciplines such as protein science, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to engineer promising clinical therapeutic candidates, conduct preclinical development studies, support clinical evaluation and contribute to Investigational New Drug IND and New Drug Application NDA filings.
The responsibilities of the Scientist will be to apply cell biology and protein biochemistry expertise to support understanding of protein therapeutic disposition, in specific, understanding of protein therapeutics Target-Mediated Drug Disposition (TMDD) and the impact of TMDD on drug catabolite formation, Pharmacokinetics and Pharmacodynamics (PKPD). The Scientist will work closely with project team representatives to design and execute (PKPD) studies and provide meaningful recommendations on therapeutic candidate profiles in support of Amgen's biologics drug discovery pipelines.
The Scientist will work in a highly dynamic environment and will collaborate with experts in bioanalytical sciences and mathematical modelling. Other responsibilities will include electronic laboratory notebook keeping and communication of results to project teams.
Master's degree and 4 years of scientific experience
Bachelor's degree and 6 years of scientific experience
Ph.D. in pharmaceutical, chemical, or biological science
2+ years of drug discovery and/or development experience
Experience with PK, PD and/or distribution of small molecule and biological therapeutics
Experience using PKPD modelling platforms
Critical thinking, and demonstrated ability to communicate with team members across broad disciplines
Excellent communication skills to allow efficient communication of biology and PK information to inform model building and subsequent learnings from modelling
A Fortune 150 company operating in nearly 100 countries around the world, we invest in highly skilled, dedicated and collaborative individuals who are ready to contribute to our mission in meaningful ways and make a difference in the lives of our patients. That's why, as a member of our cross functional, cross discipline team, we provide you with valuable opportunities to broaden your experience and maximize your potential. Focused on the industry's most compelling scientific discoveries and housed within industry leading facilities within the heart of the world's leading biotechnology hub, our colleagues are growing our pipeline through groundbreaking innovations. We believe in rewarding those who do rewarding work and are committed to providing careers that can help turn the tide of serious, life interrupting illnesses.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.