Amgen Scientist - Molecular Systems Biology in Cambridge, Massachusetts
The Translational Systems Biology group at Amgen is committed to using the latest human data and experimental platforms to transform the way drugs are discovered and developed. We are particularly interested in finding ways to reduce the use of animals while evaluating the biology of our targets and drugs, by replacing traditional toxicology assays and rodent disease models with computational genomics and computational chemistry approaches and human cell- and organoid-based technologies.
We are seeking a scientist who has demonstrated the ability to identify problems in molecular biology and human disease and then independently design and perform creative high-throughput experiments to solve those questions. This scientist will split his or her time between current projects supporting our innovative drug pipeline (pharmacogenomics GWAS, RNA-Seq interpretation, and evaluation of our drug targets using the human genetics literature) as well as projects advancing the science in our field (predictive toxicogenomics, statistical analysis of clinical trial metadata). In addition to advancing these projects, the ideal candidate will take the initiative to identify gaps in our knowledge or processes and proactively establish new experiments, methods, and internal/external collaborations by taking advantage of their technical expertise and academic connections. This position is a unique opportunity for a scientist who is looking for a role that will expose them to all stages of drug discovery and development, and who would like to grow their career by learning from a diverse group of experts in stem cell biology, structural biochemistry, toxicology, genetics, and computational biology. The successful candidate will be expected to contribute to our scientific profile and continue to lead in their field of expertise by presenting at conferences and publishing novel methods and analyses.
Master's degree and 4 years of Scientific experience
Bachelor's degree and 6 years of Scientific experience
PhD with 2+ years of high-throughput molecular and/or computational biology experience with a focus on therapeutic target discovery or drug development. Candidates' demonstrated creativity and agility with interpreting biological data is more important than specific technologies used.
Experience independently conceiving of new scientific projects with high impact, and seeing these projects all the way through to first-author publication in a high-impact journal
Familiarity with genetics and genomics databases, statistical and machine learning methods, and high-throughput techniques (such as single-cell RNA-seq, siRNA/CRISPR screens, pathway or network analysis of proteomics, metabolomics, and transcriptomics, and performing and annotating GWAS)
Necessary computer skills to implement custom analyses using a statistical programming environment (e.g. R, Matlab), a scripting language (e.g. Python, C++), the Unix command line, and wrappers around established bioinformatics tools
Well-honed ability to give scientific talks tailored to different audiences, from highly-technical lab meetings to strategy-focused executive reviews
Excellent interpersonal, collaboration, and time-management skills.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.