Amgen Principal Scientist - Metabolite Identification PKDM in Cambridge, Massachusetts

Amgen is seeking an experienced metabolite identification scientist and leader to join the Pharmacokinetics and Drug Metabolism (PKDM) department at our Kendall Square site in Cambridge, Massachusetts.

In this role you will contribute to Amgen's diverse discovery and development portfolio of therapeutic modalities with a focus on small molecule metabolite identification, elucidation of metabolic pathways and reaction mechanisms. This role will include leadership and direction of a talented group of metabolite identification scientists at our Cambridge location responsible for determining the in vitro and in vivo disposition of candidate therapeutics. You will work directly with other PKDM stakeholders at multiple Amgen research sites (Cambridge, MA, San Francisco and Thousand Oaks, CA) to influence drug discovery direction including interpretation and communication of the impact of metabolite identification data on drug safety, chemistry strategy, and clinical pharmacology planning to advance the best therapeutic candidates.

In this position the core responsibilities are to:

  • Lead a group of scientists supporting small molecule drug metabolism/metabolite identification for pipeline projects

  • Guide strategy, provide subject matter expertise and mentorship for the ADME sciences to your team, project team representatives and project teams

  • Influence the design of fit-for-purpose metabolite identification studies to achieve an appropriate level of understanding of the disposition of our molecules to best meet therapeutic and safety objectives

  • Devise, articulate, and implement strategies leading to a cohesive vision for improvement of the clearance and safety properties for candidate molecules

  • Implement new techniques, improved processes and evaluate new instrumentation

  • Identify drug metabolites using LC-MSMS and other analytical methodologies (sometimes requiring the use of radio-labelled materials)

  • Plan, design, and conduct fit-for-purpose in vitro studies and in vivo sample analysis

In addition to the core responsibilities, the position provides the opportunity to pursue scientific inquiries into the metabolism of small and large molecule biotherapeutics including mechanistic studies. The role also includes authorship and review of scientific reports, scientific papers and presentation at scientific meetings. The ideal candidate will be self-driven, enjoy working in a dynamic team environment and will have impact beyond the PKDM function as well as across sites.

Basic Qualifications:

Doctorate degree and 3 years scientific experience


Master's degree and at least 6 years of scientific experience


Bachelor's degree and at least 8 years of scientific experience

Preferred Qualifications:

Ph.D. in a pharmacokinetics, drug metabolism, biochemistry, chemistry or other relevant field

6+ years of drug discovery and development experience with a solid understanding of PK and ADME concepts

Expertise with HRMS, Thermo orbi-trap platform and knowledge/expertise of NMR

Expertise in state of the art execution and interpretation of metabolite ID data, reaction mechanism and translation to impact on program direction (e.g. influencing molecule design cycle)

Critical thinking and demonstrated ability to communicate with team members across broad disciplines

Effective oral and written communication skills

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.